TY - JOUR
T1 - Oxidative stability of liposomes composed of docosahexaenoic acid-containing phospholipids
AU - Vikbjerg, Anders Falk
AU - Andersen, T.L.
AU - Jørgensen, K.
AU - Mu, Huiling
AU - Xu, X.
PY - 2007/7/1
Y1 - 2007/7/1
N2 - Oxidative stability of liposomes made of (Docosahexaenoic acid) DHA-containing phosphatidylcholine (PC) was examined during preparation and storage. After preparation of the liposomes, the concentration of primary (conjugated dienes) and secondary oxidation products (Thiobarbituric acid-reactive substances, TBARS) were significantly higher compared to the initial value. During cold storage, formation of conjugated dienes and TBARS remained more or less constant in large unilamellar vesicles (LUV), whereas in mulitilamellar vesicles (MLV) they were seen to increase over a period of 21 days. Evaporation of solvent traces from a lipid film should preferably be done under nitrogen as vacuum evaporation was found to increase oxidation of the phospholipid.
AB - Oxidative stability of liposomes made of (Docosahexaenoic acid) DHA-containing phosphatidylcholine (PC) was examined during preparation and storage. After preparation of the liposomes, the concentration of primary (conjugated dienes) and secondary oxidation products (Thiobarbituric acid-reactive substances, TBARS) were significantly higher compared to the initial value. During cold storage, formation of conjugated dienes and TBARS remained more or less constant in large unilamellar vesicles (LUV), whereas in mulitilamellar vesicles (MLV) they were seen to increase over a period of 21 days. Evaporation of solvent traces from a lipid film should preferably be done under nitrogen as vacuum evaporation was found to increase oxidation of the phospholipid.
UR - http://www.scopus.com/inward/record.url?scp=34547455729&partnerID=8YFLogxK
U2 - 10.1007/s11746-007-1086-9
DO - 10.1007/s11746-007-1086-9
M3 - Journal article
AN - SCOPUS:34547455729
SN - 0003-021X
VL - 84
SP - 631
EP - 637
JO - Oil & Soap
JF - Oil & Soap
IS - 7
ER -