Oxidative damage to extracellular matrix and its role in human pathologies

TY - JOUR

T1 - Oxidative damage to extracellular matrix and its role in human pathologies

AU - Rees, Martin D

AU - Kennett, Eleanor C

AU - Whitelock, John M

AU - Davies, Michael Jonathan

PY - 2008/6/15

Y1 - 2008/6/15

N2 - The extracellular compartments of most biological tissues are significantly less well protected against oxidative damage than intracellular sites and there is considerable evidence for such compartments being subject to a greater oxidative stress and an altered redox balance. However, with some notable exceptions (e.g., plasma and lung lining fluid) oxidative damage within these compartments has been relatively neglected and is poorly understood. In particular information on the nature and consequences of damage to extracellular matrix is lacking despite the growing realization that changes in matrix structure can play a key role in the regulation of cellular adhesion, proliferation, migration, and cell signaling. Furthermore, the extracellular matrix is widely recognized as being a key site of cytokine and growth factor binding, and modification of matrix structure might be expected to alter such behavior. In this paper we review the potential sources of oxidative matrix damage, the changes that occur in matrix structure, and how this may affect cellular behavior. The role of such damage in the development and progression of inflammatory diseases is discussed.

AB - The extracellular compartments of most biological tissues are significantly less well protected against oxidative damage than intracellular sites and there is considerable evidence for such compartments being subject to a greater oxidative stress and an altered redox balance. However, with some notable exceptions (e.g., plasma and lung lining fluid) oxidative damage within these compartments has been relatively neglected and is poorly understood. In particular information on the nature and consequences of damage to extracellular matrix is lacking despite the growing realization that changes in matrix structure can play a key role in the regulation of cellular adhesion, proliferation, migration, and cell signaling. Furthermore, the extracellular matrix is widely recognized as being a key site of cytokine and growth factor binding, and modification of matrix structure might be expected to alter such behavior. In this paper we review the potential sources of oxidative matrix damage, the changes that occur in matrix structure, and how this may affect cellular behavior. The role of such damage in the development and progression of inflammatory diseases is discussed.

KW - Animals

KW - Arthritis

KW - Cardiovascular Diseases

KW - Cell Compartmentation

KW - Diabetes Mellitus

KW - Extracellular Matrix

KW - Free Radicals

KW - Humans

KW - Kidney Diseases

KW - Lung Diseases

KW - Nitric Oxide Synthase

KW - Oxidants

KW - Oxidative Stress

KW - Periodontal Diseases

KW - Reactive Oxygen Species

U2 - 10.1016/j.freeradbiomed.2008.03.016

DO - 10.1016/j.freeradbiomed.2008.03.016

M3 - Journal article

C2 - 18423414

SN - 0891-5849

VL - 44

SP - 1973

EP - 2001

JO - Free Radical Biology & Medicine

JF - Free Radical Biology & Medicine

IS - 12

ER -