Overweight, adipocytokines and hypertension: a prospective population-based study

Ekim Seven; Lise L N Husemoen; Kristian Wachtell; Hans Ibsen; Allan Linneberg; Jørgen L Jeppesen

doi:10.1097/HJH.0000000000000207

Overweight, adipocytokines and hypertension: a prospective population-based study

Ekim Seven, Lise L N Husemoen, Kristian Wachtell, Hans Ibsen, Allan Linneberg, Jørgen L Jeppesen

28 Citationer (Scopus)

Abstract

Objective: The adipocytokines, leptin, adiponectin, and interleukin-6, which stimulate liver C-reactive protein (CRP) production, are regarded as potential candidate intermediates between adipose tissue and overweightinduced hypertension. Methods: We examined the associations between leptin, adiponectin, and CRP levels with both prevalent and 5-year incident hypertension (IHT) in a general population of Danish adults (n=5868, 51.3% women, mean age 45.8 ± 7.9 years). Results: We recorded 2195 prevalent and 379 incident cases of hypertension. In models including leptin, CRP, adiponectin, sex, age, lifestyle risk factors, lipids, insulin, hemoglobin A1c, and in the incident model also baseline heart rate and blood pressure, only leptin of the three candidate intermediates was significantly associated with both prevalent and IHT [odds ratio (OR)=1.18, 95% confidence interval (CI) 1.06-1.32, P=0.002, and OR=1.24, 95% CI 1.01-1.54, P=0.044] for one standard deviation increase in log-transformed leptin levels, respectively. Log-transformed CRP was associated with prevalent (OR=1.16, 95% CI 1.07-1.26, P<0.001) but not IHT (OR=0.98, 95% CI 0.84-1.14, P=0.76). Logtransformed adiponectin was neither associated with prevalent nor IHT (OR=0.94, 95% CI 0.87-1.02, P=0.11 and OR=0.93, 95% CI 0.80-1.08, P=0.33). Comparing the lowest with the highest quintile of sex-specific BMI levels, there was an almost two-fold increase in IHT (OR=1.89, 95% CI 1.10-3.25, P=0.023) in the fully adjusted model. The population attributable risk estimate of IHT owing to overweight was 31%. Conclusion: Leptin, but not adiponectin or CRP, may play a mediating role in overweight-induced hypertension. However, as BMI was a strong independent predictor of hypertension, other factors than leptin must be involved in the pathogenesis of overweight-related hypertension.

Originalsprog	Engelsk
Tidsskrift	Journal of Hypertension
Vol/bind	32
Udgave nummer	7
Sider (fra-til)	1488-1494
Antal sider	7
ISSN	0263-6352
DOI	https://doi.org/10.1097/HJH.0000000000000207
Status	Udgivet - jul. 2014

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10.1097/HJH.0000000000000207

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@article{72995f051ae84f618029682ec3fa64a9,

title = "Overweight, adipocytokines and hypertension: a prospective population-based study",

abstract = "Objective: The adipocytokines, leptin, adiponectin, and interleukin-6, which stimulate liver C-reactive protein (CRP) production, are regarded as potential candidate intermediates between adipose tissue and overweightinduced hypertension. Methods: We examined the associations between leptin, adiponectin, and CRP levels with both prevalent and 5-year incident hypertension (IHT) in a general population of Danish adults (n=5868, 51.3% women, mean age 45.8 ± 7.9 years). Results: We recorded 2195 prevalent and 379 incident cases of hypertension. In models including leptin, CRP, adiponectin, sex, age, lifestyle risk factors, lipids, insulin, hemoglobin A1c, and in the incident model also baseline heart rate and blood pressure, only leptin of the three candidate intermediates was significantly associated with both prevalent and IHT [odds ratio (OR)=1.18, 95% confidence interval (CI) 1.06-1.32, P=0.002, and OR=1.24, 95% CI 1.01-1.54, P=0.044] for one standard deviation increase in log-transformed leptin levels, respectively. Log-transformed CRP was associated with prevalent (OR=1.16, 95% CI 1.07-1.26, P<0.001) but not IHT (OR=0.98, 95% CI 0.84-1.14, P=0.76). Logtransformed adiponectin was neither associated with prevalent nor IHT (OR=0.94, 95% CI 0.87-1.02, P=0.11 and OR=0.93, 95% CI 0.80-1.08, P=0.33). Comparing the lowest with the highest quintile of sex-specific BMI levels, there was an almost two-fold increase in IHT (OR=1.89, 95% CI 1.10-3.25, P=0.023) in the fully adjusted model. The population attributable risk estimate of IHT owing to overweight was 31%. Conclusion: Leptin, but not adiponectin or CRP, may play a mediating role in overweight-induced hypertension. However, as BMI was a strong independent predictor of hypertension, other factors than leptin must be involved in the pathogenesis of overweight-related hypertension.",

keywords = "Adipokines, Adiponectin, Adult, Body Mass Index, C-Reactive Protein, Denmark, Female, Humans, Hypertension, Incidence, Interleukin-6, Leptin, Male, Middle Aged, Overweight, Prevalence, Prospective Studies, Risk Factors",

author = "Ekim Seven and Husemoen, {Lise L N} and Kristian Wachtell and Hans Ibsen and Allan Linneberg and Jeppesen, {J{\o}rgen L}",

year = "2014",

month = jul,

doi = "10.1097/HJH.0000000000000207",

language = "English",

volume = "32",

pages = "1488--1494",

journal = "Journal of Hypertension",

issn = "0263-6352",

publisher = "Lippincott Williams & Wilkins, Ltd.",

number = "7",

}

TY - JOUR

T1 - Overweight, adipocytokines and hypertension

T2 - a prospective population-based study

AU - Seven, Ekim

AU - Husemoen, Lise L N

AU - Wachtell, Kristian

AU - Ibsen, Hans

AU - Linneberg, Allan

AU - Jeppesen, Jørgen L

PY - 2014/7

Y1 - 2014/7

N2 - Objective: The adipocytokines, leptin, adiponectin, and interleukin-6, which stimulate liver C-reactive protein (CRP) production, are regarded as potential candidate intermediates between adipose tissue and overweightinduced hypertension. Methods: We examined the associations between leptin, adiponectin, and CRP levels with both prevalent and 5-year incident hypertension (IHT) in a general population of Danish adults (n=5868, 51.3% women, mean age 45.8 ± 7.9 years). Results: We recorded 2195 prevalent and 379 incident cases of hypertension. In models including leptin, CRP, adiponectin, sex, age, lifestyle risk factors, lipids, insulin, hemoglobin A1c, and in the incident model also baseline heart rate and blood pressure, only leptin of the three candidate intermediates was significantly associated with both prevalent and IHT [odds ratio (OR)=1.18, 95% confidence interval (CI) 1.06-1.32, P=0.002, and OR=1.24, 95% CI 1.01-1.54, P=0.044] for one standard deviation increase in log-transformed leptin levels, respectively. Log-transformed CRP was associated with prevalent (OR=1.16, 95% CI 1.07-1.26, P<0.001) but not IHT (OR=0.98, 95% CI 0.84-1.14, P=0.76). Logtransformed adiponectin was neither associated with prevalent nor IHT (OR=0.94, 95% CI 0.87-1.02, P=0.11 and OR=0.93, 95% CI 0.80-1.08, P=0.33). Comparing the lowest with the highest quintile of sex-specific BMI levels, there was an almost two-fold increase in IHT (OR=1.89, 95% CI 1.10-3.25, P=0.023) in the fully adjusted model. The population attributable risk estimate of IHT owing to overweight was 31%. Conclusion: Leptin, but not adiponectin or CRP, may play a mediating role in overweight-induced hypertension. However, as BMI was a strong independent predictor of hypertension, other factors than leptin must be involved in the pathogenesis of overweight-related hypertension.

AB - Objective: The adipocytokines, leptin, adiponectin, and interleukin-6, which stimulate liver C-reactive protein (CRP) production, are regarded as potential candidate intermediates between adipose tissue and overweightinduced hypertension. Methods: We examined the associations between leptin, adiponectin, and CRP levels with both prevalent and 5-year incident hypertension (IHT) in a general population of Danish adults (n=5868, 51.3% women, mean age 45.8 ± 7.9 years). Results: We recorded 2195 prevalent and 379 incident cases of hypertension. In models including leptin, CRP, adiponectin, sex, age, lifestyle risk factors, lipids, insulin, hemoglobin A1c, and in the incident model also baseline heart rate and blood pressure, only leptin of the three candidate intermediates was significantly associated with both prevalent and IHT [odds ratio (OR)=1.18, 95% confidence interval (CI) 1.06-1.32, P=0.002, and OR=1.24, 95% CI 1.01-1.54, P=0.044] for one standard deviation increase in log-transformed leptin levels, respectively. Log-transformed CRP was associated with prevalent (OR=1.16, 95% CI 1.07-1.26, P<0.001) but not IHT (OR=0.98, 95% CI 0.84-1.14, P=0.76). Logtransformed adiponectin was neither associated with prevalent nor IHT (OR=0.94, 95% CI 0.87-1.02, P=0.11 and OR=0.93, 95% CI 0.80-1.08, P=0.33). Comparing the lowest with the highest quintile of sex-specific BMI levels, there was an almost two-fold increase in IHT (OR=1.89, 95% CI 1.10-3.25, P=0.023) in the fully adjusted model. The population attributable risk estimate of IHT owing to overweight was 31%. Conclusion: Leptin, but not adiponectin or CRP, may play a mediating role in overweight-induced hypertension. However, as BMI was a strong independent predictor of hypertension, other factors than leptin must be involved in the pathogenesis of overweight-related hypertension.

KW - Adipokines

KW - Adiponectin

KW - Adult

KW - Body Mass Index

KW - C-Reactive Protein

KW - Denmark

KW - Female

KW - Humans

KW - Hypertension

KW - Incidence

KW - Interleukin-6

KW - Leptin

KW - Male

KW - Middle Aged

KW - Overweight

KW - Prevalence

KW - Prospective Studies

KW - Risk Factors

U2 - 10.1097/HJH.0000000000000207

DO - 10.1097/HJH.0000000000000207

M3 - Journal article

C2 - 24805956

SN - 0263-6352

VL - 32

SP - 1488

EP - 1494

JO - Journal of Hypertension

JF - Journal of Hypertension

IS - 7

ER -

Overweight, adipocytokines and hypertension: a prospective population-based study

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