Ovarian morphology in polycystic ovary syndrome: Estimates from 2D and 3D ultrasound and magnetic resonance imaging and their correlation to anti-Müllerian hormone

Malin Nylander; Signe Frøssing; Anne H. Bjerre; Elizaveta Chabanova; Helle V. Clausen; Jens Faber; Sven O. Skouby

doi:10.1177/0284185116676656

Ovarian morphology in polycystic ovary syndrome: Estimates from 2D and 3D ultrasound and magnetic resonance imaging and their correlation to anti-Müllerian hormone

Malin Nylander^*, Signe Frøssing, Anne H. Bjerre, Elizaveta Chabanova, Helle V. Clausen, Jens Faber, Sven O. Skouby

^*Corresponding author af dette arbejde

Institut for Klinisk Medicin

4 Citationer (Scopus)

Abstract

Background Due to improved ultrasound scanners, new three-dimensional (3D) modalities, and novel Anti-Müllerian hormone (AMH)-assays, the ultrasound criteria for polycystic ovarian morphology are under debate and the appropriate thresholds are often requested. Purpose To quantify the differences in estimates of ovarian volume and antral follicle count (AFC) from two-dimensional (2D) and 3D transvaginal ultrasound (TVUS) and magnetic resonance imaging (MRI). Material and Methods A cross-sectional study on 66 overweight women with polycystic ovary syndrome (PCOS) according to Rotterdam criteria. Ovarian volume and AFC were estimated from MRI, 2D TVUS, and 3D TVUS, and serum AMH levels were assessed. Bland-Altman statistics were used for comparison. Results Participants had a median age of 29 years (age range, 19-44 years) with a mean BMI of 32.7 kg/m² (SD 4.5). Ovarian volume from 2D TVUS was 1.48 mL (95% confidence interval [CI], 0.94-2.03; P < 0.001) and 1.25 mL (95% CI, 0.62-1.87; P < 0.001) smaller than from 3D TVUS and MRI, respectively. AFC from 2D TVUS was 18% (95% CI, 13-23; P < 0.005) and 16% (95% CI, 6-25; P < 0.005) smaller than estimates from 3D TVUS and MRI, respectively. Correlations between AMH and AFC from 2D TVUS, 3D TVUS, and MRI were 0.67, 0.78, and 0.70, respectively (P < 0.001 for all). Conclusion In an overweight PCOS population, 2D TVUS underestimated ovarian volume and AFC as compared with 3D TVUS and MRI. Serum AMH correlated best with AFC from 3D TVUS, followed by MRI and 2D TVUS. The advantage of 3D TVUS might be of minor clinical importance when diagnosing PCOS, but useful when the actual AFC are of interest, e.g. in fertility counseling and research.

Originalsprog	Engelsk
Tidsskrift	Acta Radiologica
Vol/bind	58
Udgave nummer	8
Sider (fra-til)	997-1004
Antal sider	8
ISSN	0284-1851
DOI	https://doi.org/10.1177/0284185116676656
Status	Udgivet - 1 aug. 2017

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10.1177/0284185116676656

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Ovarian morphology in polycystic ovary syndrome: Estimates from 2D and 3D ultrasound and magnetic resonance imaging and their correlation to anti-Müllerian hormone. / Nylander, Malin; Frøssing, Signe; Bjerre, Anne H. et al.
I: Acta Radiologica, Bind 58, Nr. 8, 01.08.2017, s. 997-1004.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

@article{b9648e01c69f4f398c9a60e935096904,

title = "Ovarian morphology in polycystic ovary syndrome: Estimates from 2D and 3D ultrasound and magnetic resonance imaging and their correlation to anti-M{\"u}llerian hormone",

abstract = "Background Due to improved ultrasound scanners, new three-dimensional (3D) modalities, and novel Anti-M{\"u}llerian hormone (AMH)-assays, the ultrasound criteria for polycystic ovarian morphology are under debate and the appropriate thresholds are often requested. Purpose To quantify the differences in estimates of ovarian volume and antral follicle count (AFC) from two-dimensional (2D) and 3D transvaginal ultrasound (TVUS) and magnetic resonance imaging (MRI). Material and Methods A cross-sectional study on 66 overweight women with polycystic ovary syndrome (PCOS) according to Rotterdam criteria. Ovarian volume and AFC were estimated from MRI, 2D TVUS, and 3D TVUS, and serum AMH levels were assessed. Bland-Altman statistics were used for comparison. Results Participants had a median age of 29 years (age range, 19-44 years) with a mean BMI of 32.7 kg/m2 (SD 4.5). Ovarian volume from 2D TVUS was 1.48 mL (95% confidence interval [CI], 0.94-2.03; P < 0.001) and 1.25 mL (95% CI, 0.62-1.87; P < 0.001) smaller than from 3D TVUS and MRI, respectively. AFC from 2D TVUS was 18% (95% CI, 13-23; P < 0.005) and 16% (95% CI, 6-25; P < 0.005) smaller than estimates from 3D TVUS and MRI, respectively. Correlations between AMH and AFC from 2D TVUS, 3D TVUS, and MRI were 0.67, 0.78, and 0.70, respectively (P < 0.001 for all). Conclusion In an overweight PCOS population, 2D TVUS underestimated ovarian volume and AFC as compared with 3D TVUS and MRI. Serum AMH correlated best with AFC from 3D TVUS, followed by MRI and 2D TVUS. The advantage of 3D TVUS might be of minor clinical importance when diagnosing PCOS, but useful when the actual AFC are of interest, e.g. in fertility counseling and research.",

keywords = "3D transvaginal ultrasound, Anti-M{\"u}llerian hormone, magnetic resonance imaging (MRI), polycystic ovaries, polycystic ovary syndrome (PCOS)",

author = "Malin Nylander and Signe Fr{\o}ssing and Bjerre, {Anne H.} and Elizaveta Chabanova and Clausen, {Helle V.} and Jens Faber and Skouby, {Sven O.}",

year = "2017",

month = aug,

day = "1",

doi = "10.1177/0284185116676656",

language = "English",

volume = "58",

pages = "997--1004",

journal = "Acta Radiologica",

issn = "0284-1851",

publisher = "SAGE Publications",

number = "8",

}

TY - JOUR

T1 - Ovarian morphology in polycystic ovary syndrome

T2 - Estimates from 2D and 3D ultrasound and magnetic resonance imaging and their correlation to anti-Müllerian hormone

AU - Nylander, Malin

AU - Frøssing, Signe

AU - Bjerre, Anne H.

AU - Chabanova, Elizaveta

AU - Clausen, Helle V.

AU - Faber, Jens

AU - Skouby, Sven O.

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Background Due to improved ultrasound scanners, new three-dimensional (3D) modalities, and novel Anti-Müllerian hormone (AMH)-assays, the ultrasound criteria for polycystic ovarian morphology are under debate and the appropriate thresholds are often requested. Purpose To quantify the differences in estimates of ovarian volume and antral follicle count (AFC) from two-dimensional (2D) and 3D transvaginal ultrasound (TVUS) and magnetic resonance imaging (MRI). Material and Methods A cross-sectional study on 66 overweight women with polycystic ovary syndrome (PCOS) according to Rotterdam criteria. Ovarian volume and AFC were estimated from MRI, 2D TVUS, and 3D TVUS, and serum AMH levels were assessed. Bland-Altman statistics were used for comparison. Results Participants had a median age of 29 years (age range, 19-44 years) with a mean BMI of 32.7 kg/m2 (SD 4.5). Ovarian volume from 2D TVUS was 1.48 mL (95% confidence interval [CI], 0.94-2.03; P < 0.001) and 1.25 mL (95% CI, 0.62-1.87; P < 0.001) smaller than from 3D TVUS and MRI, respectively. AFC from 2D TVUS was 18% (95% CI, 13-23; P < 0.005) and 16% (95% CI, 6-25; P < 0.005) smaller than estimates from 3D TVUS and MRI, respectively. Correlations between AMH and AFC from 2D TVUS, 3D TVUS, and MRI were 0.67, 0.78, and 0.70, respectively (P < 0.001 for all). Conclusion In an overweight PCOS population, 2D TVUS underestimated ovarian volume and AFC as compared with 3D TVUS and MRI. Serum AMH correlated best with AFC from 3D TVUS, followed by MRI and 2D TVUS. The advantage of 3D TVUS might be of minor clinical importance when diagnosing PCOS, but useful when the actual AFC are of interest, e.g. in fertility counseling and research.

AB - Background Due to improved ultrasound scanners, new three-dimensional (3D) modalities, and novel Anti-Müllerian hormone (AMH)-assays, the ultrasound criteria for polycystic ovarian morphology are under debate and the appropriate thresholds are often requested. Purpose To quantify the differences in estimates of ovarian volume and antral follicle count (AFC) from two-dimensional (2D) and 3D transvaginal ultrasound (TVUS) and magnetic resonance imaging (MRI). Material and Methods A cross-sectional study on 66 overweight women with polycystic ovary syndrome (PCOS) according to Rotterdam criteria. Ovarian volume and AFC were estimated from MRI, 2D TVUS, and 3D TVUS, and serum AMH levels were assessed. Bland-Altman statistics were used for comparison. Results Participants had a median age of 29 years (age range, 19-44 years) with a mean BMI of 32.7 kg/m2 (SD 4.5). Ovarian volume from 2D TVUS was 1.48 mL (95% confidence interval [CI], 0.94-2.03; P < 0.001) and 1.25 mL (95% CI, 0.62-1.87; P < 0.001) smaller than from 3D TVUS and MRI, respectively. AFC from 2D TVUS was 18% (95% CI, 13-23; P < 0.005) and 16% (95% CI, 6-25; P < 0.005) smaller than estimates from 3D TVUS and MRI, respectively. Correlations between AMH and AFC from 2D TVUS, 3D TVUS, and MRI were 0.67, 0.78, and 0.70, respectively (P < 0.001 for all). Conclusion In an overweight PCOS population, 2D TVUS underestimated ovarian volume and AFC as compared with 3D TVUS and MRI. Serum AMH correlated best with AFC from 3D TVUS, followed by MRI and 2D TVUS. The advantage of 3D TVUS might be of minor clinical importance when diagnosing PCOS, but useful when the actual AFC are of interest, e.g. in fertility counseling and research.

KW - 3D transvaginal ultrasound

KW - Anti-Müllerian hormone

KW - magnetic resonance imaging (MRI)

KW - polycystic ovaries

KW - polycystic ovary syndrome (PCOS)

U2 - 10.1177/0284185116676656

DO - 10.1177/0284185116676656

M3 - Journal article

C2 - 28273731

AN - SCOPUS:85021137410

SN - 0284-1851

VL - 58

SP - 997

EP - 1004

JO - Acta Radiologica

JF - Acta Radiologica

IS - 8

ER -

Ovarian morphology in polycystic ovary syndrome: Estimates from 2D and 3D ultrasound and magnetic resonance imaging and their correlation to anti-Müllerian hormone

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