Outstanding challenges for rotavirus vaccine introduction in low-income countries - a systematic review

Marte Ustrup; Lizell B. Madsen; Ib C. Bygbjerg; Flemming Konradsen

Outstanding challenges for rotavirus vaccine introduction in low-income countries - a systematic review

Marte Ustrup^*, Lizell B. Madsen, Ib C. Bygbjerg, Flemming Konradsen

^*Corresponding author af dette arbejde

9 Citationer (Scopus)

Abstract

Rotavirus infections are the most common cause of severe diarrhoea in children worldwide. Two internationally licensed rotavirus vaccines have proven to be efficacious in middle- and high-income countries and they could potentially be valuable tools for the prevention of rotavirusassociated diarrhoea in low-income countries where the disease burden is greatest. However, before the vaccines can be introduced into the national immunisation programmes in these countries, many challenges related to the financing of vaccine purchase, the cold chain capacity and vaccine efficacy must be overcome. There is also a need for political commitment to prevent rotavirus infections as well as a need for an overall strengthening of the health systems in low-income countries. If these challenges were met, rotavirus vaccination could substantially improve child health and survival from rotavirusassociated diarrhoea.

Originalsprog	Engelsk
Tidsskrift	Danish Medical Bulletin
Vol/bind	58
Udgave nummer	10
Sider (fra-til)	8
Antal sider	1
Status	Udgivet - okt. 2011
Udgivet eksternt	Ja

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abstract = "Rotavirus infections are the most common cause of severe diarrhoea in children worldwide. Two internationally licensed rotavirus vaccines have proven to be efficacious in middle- and high-income countries and they could potentially be valuable tools for the prevention of rotavirusassociated diarrhoea in low-income countries where the disease burden is greatest. However, before the vaccines can be introduced into the national immunisation programmes in these countries, many challenges related to the financing of vaccine purchase, the cold chain capacity and vaccine efficacy must be overcome. There is also a need for political commitment to prevent rotavirus infections as well as a need for an overall strengthening of the health systems in low-income countries. If these challenges were met, rotavirus vaccination could substantially improve child health and survival from rotavirusassociated diarrhoea.",

author = "Marte Ustrup and Madsen, {Lizell B.} and Bygbjerg, {Ib C.} and Flemming Konradsen",

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AU - Bygbjerg, Ib C.

AU - Konradsen, Flemming

PY - 2011/10

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N2 - Rotavirus infections are the most common cause of severe diarrhoea in children worldwide. Two internationally licensed rotavirus vaccines have proven to be efficacious in middle- and high-income countries and they could potentially be valuable tools for the prevention of rotavirusassociated diarrhoea in low-income countries where the disease burden is greatest. However, before the vaccines can be introduced into the national immunisation programmes in these countries, many challenges related to the financing of vaccine purchase, the cold chain capacity and vaccine efficacy must be overcome. There is also a need for political commitment to prevent rotavirus infections as well as a need for an overall strengthening of the health systems in low-income countries. If these challenges were met, rotavirus vaccination could substantially improve child health and survival from rotavirusassociated diarrhoea.

AB - Rotavirus infections are the most common cause of severe diarrhoea in children worldwide. Two internationally licensed rotavirus vaccines have proven to be efficacious in middle- and high-income countries and they could potentially be valuable tools for the prevention of rotavirusassociated diarrhoea in low-income countries where the disease burden is greatest. However, before the vaccines can be introduced into the national immunisation programmes in these countries, many challenges related to the financing of vaccine purchase, the cold chain capacity and vaccine efficacy must be overcome. There is also a need for political commitment to prevent rotavirus infections as well as a need for an overall strengthening of the health systems in low-income countries. If these challenges were met, rotavirus vaccination could substantially improve child health and survival from rotavirusassociated diarrhoea.

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Outstanding challenges for rotavirus vaccine introduction in low-income countries - a systematic review

Abstract

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