TY - JOUR
T1 - Outcomes of transplantations of cryopreserved ovarian tissue to 41 women in Denmark
AU - Jensen, A K
AU - Kristensen, S G
AU - Macklon, K T
AU - Jeppesen, J V
AU - Fedder, J
AU - Ernst, E
AU - Andersen, C Y
N1 - © The Author 2015. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: [email protected].
PY - 2015/12
Y1 - 2015/12
N2 - study question: What are the results of transplanting cryopreserved ovarian tissue? summary answer: The transplanted ovarian tissue can last up to 10 years, with no relapses following the 53 transplantations, and the chance of a successful pregnancy is currently around one in three for those with a pregnancy-wish. what is known already: Cryopreservation of ovarian tissue is now gaining ground as a valid method for fertility preservation. More than 36 children worldwide have now been born following this procedure. study design, size, duration: This is a retrospective cohort study of 41 women who had thawed ovarian tissue transplanted 53 times over a period of 10 years, incluDing 1 patient who was lost to follow-up. participants/materials, setting,methods: The 41 Danish women,who had in total 53 transplantations, were followed for ovarian function and fertility outcome. Safety was assessed by monitoring relapse in cancer survivors. main results, and the role of chance: Among 32women with a pregnancy-wish, 10 (31%) had a child/children (14 children in total); this included 1 woman with a third trimester on-going pregnancy. In addition, two legal abortions and one second trimester miscarriage occurred.Atotal of 24 clinical pregnancies were established in the 32womenwith a pregnancy-wish. The tissue remained functional for close to 10 years in some cases and lasted only a short period in others. Three relapses occurred but were unlikely to be due to the transplanted tissue. limitations, reasons for caution: Self-report through questionnaires with only in-one hospital formalised follow-up of transplanted patients could result in unreported miscarriages. The longevity of the tissue may vary by few months compared with those reported because some patients simply could not remember the date when the tissue became non-functional.
AB - study question: What are the results of transplanting cryopreserved ovarian tissue? summary answer: The transplanted ovarian tissue can last up to 10 years, with no relapses following the 53 transplantations, and the chance of a successful pregnancy is currently around one in three for those with a pregnancy-wish. what is known already: Cryopreservation of ovarian tissue is now gaining ground as a valid method for fertility preservation. More than 36 children worldwide have now been born following this procedure. study design, size, duration: This is a retrospective cohort study of 41 women who had thawed ovarian tissue transplanted 53 times over a period of 10 years, incluDing 1 patient who was lost to follow-up. participants/materials, setting,methods: The 41 Danish women,who had in total 53 transplantations, were followed for ovarian function and fertility outcome. Safety was assessed by monitoring relapse in cancer survivors. main results, and the role of chance: Among 32women with a pregnancy-wish, 10 (31%) had a child/children (14 children in total); this included 1 woman with a third trimester on-going pregnancy. In addition, two legal abortions and one second trimester miscarriage occurred.Atotal of 24 clinical pregnancies were established in the 32womenwith a pregnancy-wish. The tissue remained functional for close to 10 years in some cases and lasted only a short period in others. Three relapses occurred but were unlikely to be due to the transplanted tissue. limitations, reasons for caution: Self-report through questionnaires with only in-one hospital formalised follow-up of transplanted patients could result in unreported miscarriages. The longevity of the tissue may vary by few months compared with those reported because some patients simply could not remember the date when the tissue became non-functional.
U2 - 10.1093/humrep/dev230
DO - 10.1093/humrep/dev230
M3 - Journal article
C2 - 26443605
SN - 0268-1161
VL - 30
SP - 2838
EP - 2845
JO - Human Reproduction
JF - Human Reproduction
IS - 12
ER -
