Outcome measures in spinal cord injury: recent assessments and recommendations for future directions

TY - JOUR

T1 - Outcome measures in spinal cord injury: recent assessments and recommendations for future directions

AU - Alexander, M S

AU - Anderson, K D

AU - Biering-Sørensen, Fin

AU - Blight, A R

AU - Brannon, R

AU - Bryce, T N

AU - Creasey, G

AU - Catz, A

AU - Curt, A

AU - Donovan, W

AU - Ditunno, J

AU - Ellaway, P

AU - Finnerup, N B

AU - Graves, D E

AU - Haynes, B A

AU - Heinemann, A W

AU - Jackson, A B

AU - Johnston, M V

AU - Kalpakjian, C Z

AU - Kleitman, N

AU - Krassioukov, A

AU - Krogh, K

AU - Lammertse, D

AU - Magasi, S

AU - Mulcahey, M J

AU - Schurch, B

AU - Sherwood, A

AU - Steeves, J D

AU - Stiens, S

AU - Tulsky, D S

AU - van Hedel, H J A

AU - Whiteneck, G

N1 - Keywords: Clinical Trials as Topic; Humans; Outcome Assessment (Health Care); Spinal Cord Injuries; Treatment Outcome

PY - 2009

Y1 - 2009

N2 - Study design:Review by the spinal cord outcomes partnership endeavor (SCOPE), which is a broad-based international consortium of scientists and clinical researchers representing academic institutions, industry, government agencies, not-for-profit organizations and foundations. Objectives:Assessment of current and evolving tools for evaluating human spinal cord injury (SCI) outcomes for both clinical diagnosis and clinical research studies. Methods:a framework for the appraisal of evidence of metric properties was used to examine outcome tools or tests for accuracy, sensitivity, reliability and validity for human SCI. Results:Imaging, neurological, functional, autonomic, sexual health, bladder/bowel, pain and psychosocial tools were evaluated. Several specific tools for human SCI studies have or are being developed to allow the more accurate determination for a clinically meaningful benefit (improvement in functional outcome or quality of life) being achieved as a result of a therapeutic intervention. Conclusion:Significant progress has been made, but further validation studies are required to identify the most appropriate tools for specific targets in a human SCI study or clinical trial.

AB - Study design:Review by the spinal cord outcomes partnership endeavor (SCOPE), which is a broad-based international consortium of scientists and clinical researchers representing academic institutions, industry, government agencies, not-for-profit organizations and foundations. Objectives:Assessment of current and evolving tools for evaluating human spinal cord injury (SCI) outcomes for both clinical diagnosis and clinical research studies. Methods:a framework for the appraisal of evidence of metric properties was used to examine outcome tools or tests for accuracy, sensitivity, reliability and validity for human SCI. Results:Imaging, neurological, functional, autonomic, sexual health, bladder/bowel, pain and psychosocial tools were evaluated. Several specific tools for human SCI studies have or are being developed to allow the more accurate determination for a clinically meaningful benefit (improvement in functional outcome or quality of life) being achieved as a result of a therapeutic intervention. Conclusion:Significant progress has been made, but further validation studies are required to identify the most appropriate tools for specific targets in a human SCI study or clinical trial.

U2 - 10.1038/sc.2009.18

DO - 10.1038/sc.2009.18

M3 - Journal article

C2 - 19381157

SN - 1362-4393

VL - 47

SP - 582

EP - 591

JO - Spinal Cord

JF - Spinal Cord

IS - 8

ER -