Osteoarthritis, obesity and weight loss: evidence, hypotheses and horizons – a scoping review

TY - JOUR

T1 - Osteoarthritis, obesity and weight loss

T2 - evidence, hypotheses and horizons – a scoping review

AU - Bliddal, Henning

AU - Leeds, A R

AU - Christensen, Robin Daniel Kjersgaard

N1 - © 2014 The Authors. Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity.

PY - 2014/7

Y1 - 2014/7

N2 - Summary: Obesity is widely acknowledged as a risk factor for both the incidence and progression of osteoarthritis, and has a negative influence on outcomes. Loss of at least 10% of body weight, coupled with exercise, is recognized as a cornerstone in the management of obese patients with osteoarthritis, and can lead to significant improvement in symptoms, pain relief, physical function and health-related quality of life. However, questions still remain surrounding optimal management. Given the significant health, social and economic burden of osteoarthritis, especially in obese patients, it is imperative to advance our knowledge of osteoarthritis and obesity, and apply this to improving care and outcomes. This paper overviews what is already known about osteoarthritis and obesity, discusses current key challenges and ongoing hypotheses arising from research in these areas, and finally, postulates what the future may hold in terms of new horizons for obese patients with osteoarthritis.

AB - Summary: Obesity is widely acknowledged as a risk factor for both the incidence and progression of osteoarthritis, and has a negative influence on outcomes. Loss of at least 10% of body weight, coupled with exercise, is recognized as a cornerstone in the management of obese patients with osteoarthritis, and can lead to significant improvement in symptoms, pain relief, physical function and health-related quality of life. However, questions still remain surrounding optimal management. Given the significant health, social and economic burden of osteoarthritis, especially in obese patients, it is imperative to advance our knowledge of osteoarthritis and obesity, and apply this to improving care and outcomes. This paper overviews what is already known about osteoarthritis and obesity, discusses current key challenges and ongoing hypotheses arising from research in these areas, and finally, postulates what the future may hold in terms of new horizons for obese patients with osteoarthritis.

KW - Diet, Reducing

KW - Disease Progression

KW - Humans

KW - Obesity

KW - Osteoarthritis

KW - Prevalence

KW - Quality of Life

KW - Risk Factors

KW - Weight Loss

U2 - 10.1111/obr.12173

DO - 10.1111/obr.12173

M3 - Review

C2 - 24751192

SN - 1467-7881

VL - 15

SP - 578

EP - 586

JO - Obesity Reviews

JF - Obesity Reviews

IS - 7

ER -