Orbital Lymphoma - An International Multicenter Retrospective Study

Tine Gadegaard Olsen; Frederik Holm; Lauge Hjorth Mikkelsen; Peter Kristian Rasmussen; Sarah E Coupland; Bita Esmaeli; Paul T Finger; Gerardo F Graue; Hans E Grossniklaus; Santosh G Honavar; Jwu Jin Khong; Penelope A McKelvie; Kaustubh Mulay; Lene Dissing Sjö; Geeta K Vemuganti; Bradley A Thuro; Steffen Heegaard

doi:10.1016/j.ajo.2018.11.002

Orbital Lymphoma - An International Multicenter Retrospective Study

Tine Gadegaard Olsen, Frederik Holm, Lauge Hjorth Mikkelsen, Peter Kristian Rasmussen, Sarah E Coupland, Bita Esmaeli, Paul T Finger, Gerardo F Graue, Hans E Grossniklaus, Santosh G Honavar, Jwu Jin Khong, Penelope A McKelvie, Kaustubh Mulay, Lene Dissing Sjö, Geeta K Vemuganti, Bradley A Thuro, Steffen Heegaard

Institut for Klinisk Medicin

21 Citationer (Scopus)

Abstract

PURPOSE: To investigate and characterize the clinical features of subtype-specific orbital lymphoma.

DESIGN: Retrospective, interventional case series.

METHODS: The study included 7 international eye cancer centers. Patient data were collected from January 1, 1980 through December 31, 2017. A total of 797 patients with a histologically verified orbital lymphoma were included. The primary endpoints were overall survival, disease-specific survival, and progression-free survival.

RESULTS: The median age was 64 years, and 51% of patients (n = 407) were male. The majority of lymphomas were of B-cell origin (98%, n = 779). Extranodal marginal zone B-cell lymphoma (EMZL) was the most frequent subtype (57%, n = 452), followed by diffuse large B-cell lymphoma (DLBCL) (15%, n = 118), follicular lymphoma (FL) (11%, n = 91), and mantle cell lymphoma (MCL) (8%, n = 66). Localized Ann Arbor stage IE EMZL and FL were frequently treated with external beam radiation therapy. DLBCL, MCL, and disseminated EMZL and FL were primarily treated with chemotherapy. EMZL and FL patients had a markedly better prognosis (10-year disease-specific survival of 92% and 71%, respectively) than DLBCL and MCL patients (10-year disease-specific survival of 41% and 32%, respectively).

CONCLUSIONS: Four lymphoma subtypes were primarily found in patients with orbital lymphoma: EMZL, DLBCL, FL, and MCL. The histologic subtype was found to be the main predictor for outcome, with EMZL and FL patients having a markedly better prognosis than DLBCL and MCL.

Originalsprog	Engelsk
Tidsskrift	American Journal of Ophthalmology
Vol/bind	199
Sider (fra-til)	44-57
Antal sider	14
ISSN	0002-9394
DOI	https://doi.org/10.1016/j.ajo.2018.11.002
Status	Udgivet - mar. 2019

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10.1016/j.ajo.2018.11.002

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Olsen, T. G., Holm, F., Mikkelsen, L. H., Rasmussen, P. K., Coupland, S. E., Esmaeli, B., Finger, P. T., Graue, G. F., Grossniklaus, H. E., Honavar, S. G., Khong, J. J., McKelvie, P. A., Mulay, K., Sjö, L. D., Vemuganti, G. K., Thuro, B. A., & Heegaard, S. (2019). Orbital Lymphoma - An International Multicenter Retrospective Study. American Journal of Ophthalmology, 199, 44-57. https://doi.org/10.1016/j.ajo.2018.11.002

Olsen, TG, Holm, F, Mikkelsen, LH, Rasmussen, PK, Coupland, SE, Esmaeli, B, Finger, PT, Graue, GF, Grossniklaus, HE, Honavar, SG, Khong, JJ, McKelvie, PA, Mulay, K, Sjö, LD, Vemuganti, GK, Thuro, BA & Heegaard, S 2019, 'Orbital Lymphoma - An International Multicenter Retrospective Study', American Journal of Ophthalmology, bind 199, s. 44-57. https://doi.org/10.1016/j.ajo.2018.11.002

@article{d1e28188b88d46dfb57d6e1c6fc8050b,

title = "Orbital Lymphoma - An International Multicenter Retrospective Study",

abstract = "PURPOSE: To investigate and characterize the clinical features of subtype-specific orbital lymphoma.DESIGN: Retrospective, interventional case series.METHODS: The study included 7 international eye cancer centers. Patient data were collected from January 1, 1980 through December 31, 2017. A total of 797 patients with a histologically verified orbital lymphoma were included. The primary endpoints were overall survival, disease-specific survival, and progression-free survival.RESULTS: The median age was 64 years, and 51% of patients (n = 407) were male. The majority of lymphomas were of B-cell origin (98%, n = 779). Extranodal marginal zone B-cell lymphoma (EMZL) was the most frequent subtype (57%, n = 452), followed by diffuse large B-cell lymphoma (DLBCL) (15%, n = 118), follicular lymphoma (FL) (11%, n = 91), and mantle cell lymphoma (MCL) (8%, n = 66). Localized Ann Arbor stage IE EMZL and FL were frequently treated with external beam radiation therapy. DLBCL, MCL, and disseminated EMZL and FL were primarily treated with chemotherapy. EMZL and FL patients had a markedly better prognosis (10-year disease-specific survival of 92% and 71%, respectively) than DLBCL and MCL patients (10-year disease-specific survival of 41% and 32%, respectively).CONCLUSIONS: Four lymphoma subtypes were primarily found in patients with orbital lymphoma: EMZL, DLBCL, FL, and MCL. The histologic subtype was found to be the main predictor for outcome, with EMZL and FL patients having a markedly better prognosis than DLBCL and MCL.",

author = "Olsen, {Tine Gadegaard} and Frederik Holm and Mikkelsen, {Lauge Hjorth} and Rasmussen, {Peter Kristian} and Coupland, {Sarah E} and Bita Esmaeli and Finger, {Paul T} and Graue, {Gerardo F} and Grossniklaus, {Hans E} and Honavar, {Santosh G} and Khong, {Jwu Jin} and McKelvie, {Penelope A} and Kaustubh Mulay and Sj{\"o}, {Lene Dissing} and Vemuganti, {Geeta K} and Thuro, {Bradley A} and Steffen Heegaard",

year = "2019",

month = mar,

doi = "10.1016/j.ajo.2018.11.002",

language = "English",

volume = "199",

pages = "44--57",

journal = "American Journal of Ophthalmology",

issn = "0002-9394",

publisher = "Elsevier",

}

TY - JOUR

T1 - Orbital Lymphoma - An International Multicenter Retrospective Study

AU - Olsen, Tine Gadegaard

AU - Holm, Frederik

AU - Mikkelsen, Lauge Hjorth

AU - Rasmussen, Peter Kristian

AU - Coupland, Sarah E

AU - Esmaeli, Bita

AU - Finger, Paul T

AU - Graue, Gerardo F

AU - Grossniklaus, Hans E

AU - Honavar, Santosh G

AU - Khong, Jwu Jin

AU - McKelvie, Penelope A

AU - Mulay, Kaustubh

AU - Sjö, Lene Dissing

AU - Vemuganti, Geeta K

AU - Thuro, Bradley A

AU - Heegaard, Steffen

PY - 2019/3

Y1 - 2019/3

N2 - PURPOSE: To investigate and characterize the clinical features of subtype-specific orbital lymphoma.DESIGN: Retrospective, interventional case series.METHODS: The study included 7 international eye cancer centers. Patient data were collected from January 1, 1980 through December 31, 2017. A total of 797 patients with a histologically verified orbital lymphoma were included. The primary endpoints were overall survival, disease-specific survival, and progression-free survival.RESULTS: The median age was 64 years, and 51% of patients (n = 407) were male. The majority of lymphomas were of B-cell origin (98%, n = 779). Extranodal marginal zone B-cell lymphoma (EMZL) was the most frequent subtype (57%, n = 452), followed by diffuse large B-cell lymphoma (DLBCL) (15%, n = 118), follicular lymphoma (FL) (11%, n = 91), and mantle cell lymphoma (MCL) (8%, n = 66). Localized Ann Arbor stage IE EMZL and FL were frequently treated with external beam radiation therapy. DLBCL, MCL, and disseminated EMZL and FL were primarily treated with chemotherapy. EMZL and FL patients had a markedly better prognosis (10-year disease-specific survival of 92% and 71%, respectively) than DLBCL and MCL patients (10-year disease-specific survival of 41% and 32%, respectively).CONCLUSIONS: Four lymphoma subtypes were primarily found in patients with orbital lymphoma: EMZL, DLBCL, FL, and MCL. The histologic subtype was found to be the main predictor for outcome, with EMZL and FL patients having a markedly better prognosis than DLBCL and MCL.

AB - PURPOSE: To investigate and characterize the clinical features of subtype-specific orbital lymphoma.DESIGN: Retrospective, interventional case series.METHODS: The study included 7 international eye cancer centers. Patient data were collected from January 1, 1980 through December 31, 2017. A total of 797 patients with a histologically verified orbital lymphoma were included. The primary endpoints were overall survival, disease-specific survival, and progression-free survival.RESULTS: The median age was 64 years, and 51% of patients (n = 407) were male. The majority of lymphomas were of B-cell origin (98%, n = 779). Extranodal marginal zone B-cell lymphoma (EMZL) was the most frequent subtype (57%, n = 452), followed by diffuse large B-cell lymphoma (DLBCL) (15%, n = 118), follicular lymphoma (FL) (11%, n = 91), and mantle cell lymphoma (MCL) (8%, n = 66). Localized Ann Arbor stage IE EMZL and FL were frequently treated with external beam radiation therapy. DLBCL, MCL, and disseminated EMZL and FL were primarily treated with chemotherapy. EMZL and FL patients had a markedly better prognosis (10-year disease-specific survival of 92% and 71%, respectively) than DLBCL and MCL patients (10-year disease-specific survival of 41% and 32%, respectively).CONCLUSIONS: Four lymphoma subtypes were primarily found in patients with orbital lymphoma: EMZL, DLBCL, FL, and MCL. The histologic subtype was found to be the main predictor for outcome, with EMZL and FL patients having a markedly better prognosis than DLBCL and MCL.

U2 - 10.1016/j.ajo.2018.11.002

DO - 10.1016/j.ajo.2018.11.002

M3 - Journal article

C2 - 30419193

SN - 0002-9394

VL - 199

SP - 44

EP - 57

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

ER -

Orbital Lymphoma - An International Multicenter Retrospective Study

Abstract

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