Oral manganese for liver imaging at three different field strengths

Henrik S. Thomsen*, Vibeke Loegager, Henrik Noergaard, Elizaveta Chabanova, Jakob M. Moller, Jesper Sonne

*Corresponding author af dette arbejde
13 Citationer (Scopus)

Abstract

Rationale and Objectives. To study the magnetic resonance imaging signal intensity of the liver and gall bladder before and after ingestion of a new oral manganese containing contrast medium at three different field strengths. Materials and Methods. Twelve healthy male volunteers (mean age, 24.9 years; range, 20-39 years) underwent abdominal magnetic resonance imaging (T 2W COR, T1W COR, T1W TRA) at 0.23T, 0.6T, and 1.5 T before and after the contrast administration. The duration of fasting was identical before the two studies. Volunteers were randomized into two equal groups (n = 6) to ingest either half or full strength CMC-001 providing either 0.8 or 1.6.g MnCl2 plus absorption promoters. The CMC-001 dose was dissolved in 400 mL water and ingested 21/2 hours before imaging. The resulting images were evaluated with regard to visualization of the liver and the gall bladder by three radiologists. The signal intensity of the liver was also measured. Blood and urine samples were collected before and after ingestion of CMC-001. Results. The intake of CMC-001 caused a significant increase in the signal intensity of the liver at all three field strengths and at both dosages (up to 90%) on the T1W images. The internal structure of the liver was significantly better delineated. The bile in gall bladder was bright after ingestion of the low dose, but dark after the full dose. On the T2W images, CMC-001 lowered the signal intensity of liver with up to 30%. CMC-001 had a slight metallic taste, but of no importance according to the volunteers. No systematic adverse reactions caused by the contrast medium were registered. No changes in the blood levels of various routine parameters were measured. Conclusion. It is possible to increase the signal intensity of the liver significantly by oral intake of essential nutritional elements including manganese. The imaging window is more than 2 hours.

OriginalsprogEngelsk
TidsskriftAcademic Radiology
Vol/bind11
Udgave nummer6
Sider (fra-til)630-636
Antal sider7
ISSN1076-6332
DOI
StatusUdgivet - 1 jan. 2004

Fingeraftryk

Dyk ned i forskningsemnerne om 'Oral manganese for liver imaging at three different field strengths'. Sammen danner de et unikt fingeraftryk.

Citationsformater