Optogenetic control of human neurons in organotypic brain cultures

TY - JOUR

T1 - Optogenetic control of human neurons in organotypic brain cultures

AU - Andersson, My

AU - Avaliani, Natalia

AU - Svensson, Andreas

AU - Wickham, Jenny

AU - Pinborg, Lars H

AU - Jespersen, Bo

AU - Christiansen, Søren H

AU - Bengzon, Johan

AU - Woldbye, David P D

AU - Kokaia, Merab

PY - 2016/4/21

Y1 - 2016/4/21

N2 - Optogenetics is one of the most powerful tools in neuroscience, allowing for selective control of specific neuronal populations in the brain of experimental animals, including mammals. We report, for the first time, the application of optogenetic tools to human brain tissue providing a proof-of-concept for the use of optogenetics in neuromodulation of human cortical and hippocampal neurons as a possible tool to explore network mechanisms and develop future therapeutic strategies.

AB - Optogenetics is one of the most powerful tools in neuroscience, allowing for selective control of specific neuronal populations in the brain of experimental animals, including mammals. We report, for the first time, the application of optogenetic tools to human brain tissue providing a proof-of-concept for the use of optogenetics in neuromodulation of human cortical and hippocampal neurons as a possible tool to explore network mechanisms and develop future therapeutic strategies.

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1038/srep24818

DO - 10.1038/srep24818

M3 - Journal article

C2 - 27098488

SN - 2045-2322

VL - 6

JO - Scientific Reports

JF - Scientific Reports

M1 - 24818

ER -