Optic nerve pH and PO2: the effects of carbonic anhydrase inhibition, and metabolic and respiratory acidosis

TY - JOUR

T1 - Optic nerve pH and PO2

T2 - the effects of carbonic anhydrase inhibition, and metabolic and respiratory acidosis

AU - Pedersen, Daniella B

AU - Stefánsson, Einar

AU - Kiilgaard, Jens Folke

AU - Jensen, Peter K

AU - Eysteinsson, Thor

AU - Bang, Kurt

AU - la Cour, Morten

PY - 2006

Y1 - 2006

N2 - Earlier studies have demonstrated that carbonic anhydrase inhibitors (CAIs) increase optic nerve oxygen tension (ONPO(2)) in pigs. We hypothesized that the mechanism of this effect was either a CO(2) increase or a pH decrease in tissue and blood. To test this hypothesis we investigated and compared how optic nerve pH (ONpH) and ONPO(2) are affected by: (1) carbonic anhydrase inhibition; (2) respiratory acidosis, and (3) metabolic acidosis. We measured ONpH with a glass pH electrode and ONPO(2) with a polarographic oxygen electrode. One of the electrodes was placed in the vitreous cavity 0.5 mm over the optic nerve in the eyes of domestic pigs.

AB - Earlier studies have demonstrated that carbonic anhydrase inhibitors (CAIs) increase optic nerve oxygen tension (ONPO(2)) in pigs. We hypothesized that the mechanism of this effect was either a CO(2) increase or a pH decrease in tissue and blood. To test this hypothesis we investigated and compared how optic nerve pH (ONpH) and ONPO(2) are affected by: (1) carbonic anhydrase inhibition; (2) respiratory acidosis, and (3) metabolic acidosis. We measured ONpH with a glass pH electrode and ONPO(2) with a polarographic oxygen electrode. One of the electrodes was placed in the vitreous cavity 0.5 mm over the optic nerve in the eyes of domestic pigs.

U2 - http://dx.doi.org/10.1111/j.1600-0420.2006.00709.x

DO - http://dx.doi.org/10.1111/j.1600-0420.2006.00709.x

M3 - Journal article

SN - 1755-375X

VL - 84

SP - 475

EP - 480

JO - Acta Ophthalmologica

JF - Acta Ophthalmologica

IS - 4

ER -