Oncogenic cooperation between SOCS family proteins and EGFR identified using a Drosophila epithelial transformation model

TY - JOUR

T1 - Oncogenic cooperation between SOCS family proteins and EGFR identified using a Drosophila epithelial transformation model

AU - Herranz, Héctor

AU - Hong, Xin

AU - Nguyen, Thanh Hung

AU - Voorhoeve, P Mathijs

AU - Cohen, Stephen M

PY - 2012/7/15

Y1 - 2012/7/15

N2 - MicroRNAs (miRNAs) are emerging as cooperating factors that promote the activity of oncogenes in tumor formation and disease progression. This poses the challenge of identifying the miRNA targets responsible for these interactions. In this study, we identify the growth regulatory miRNA bantam and its target, Socs36E, as cooperating factors in EGFR-driven tumorigenesis and metastasis in a Drosophila model of epithelial transformation. bantam promotes growth by limiting expression of Socs36E, which functions as a negative growth regulator. Socs36E has only a modest effect on growth on its own, but behaves as a tumor suppressor in combination with EGFR activation. The human ortholog of SOCS36E, SOCS5, behaves as a candidate tumor suppressor in cellular transformation in cooperation with EGFR/RAS pathway activation.

AB - MicroRNAs (miRNAs) are emerging as cooperating factors that promote the activity of oncogenes in tumor formation and disease progression. This poses the challenge of identifying the miRNA targets responsible for these interactions. In this study, we identify the growth regulatory miRNA bantam and its target, Socs36E, as cooperating factors in EGFR-driven tumorigenesis and metastasis in a Drosophila model of epithelial transformation. bantam promotes growth by limiting expression of Socs36E, which functions as a negative growth regulator. Socs36E has only a modest effect on growth on its own, but behaves as a tumor suppressor in combination with EGFR activation. The human ortholog of SOCS36E, SOCS5, behaves as a candidate tumor suppressor in cellular transformation in cooperation with EGFR/RAS pathway activation.

KW - Animals

KW - Cell Transformation, Neoplastic

KW - Disease Models, Animal

KW - Drosophila Proteins

KW - Drosophila melanogaster

KW - Epithelial Cells

KW - Humans

KW - MicroRNAs

KW - Receptor, Epidermal Growth Factor

KW - Receptors, Invertebrate Peptide

KW - Suppressor of Cytokine Signaling Proteins

KW - Tumor Suppressor Proteins

KW - ras Proteins

U2 - 10.1101/gad.192021.112

DO - 10.1101/gad.192021.112

M3 - Journal article

C2 - 22802531

SN - 0890-9369

VL - 26

SP - 1602

EP - 1611

JO - Genes & Development

JF - Genes & Development

IS - 14

ER -