On the methodology of drug trials in migraine with aura

Anne Werner Hauge; Anders Hougaard; Jes Olesen

doi:10.1177/0333102409359091

On the methodology of drug trials in migraine with aura

Anne Werner Hauge, Anders Hougaard, Jes Olesen

8 Citationer (Scopus)

Abstract

INTRODUCTION: Specific problems occur in clinical treatment trials for migraine with aura that differ from those encountered in treatment trials for migraine without aura. DISCUSSION: Based on our experience with four such trials, we point to a number of possible solutions and outline areas for future inquiry. We make recommendations about subject selection; the choice, definition and assessment of outcome measures; optimal treatments in relation to aura and headache; and we provide samples of study report forms used to record occurrence of aura and headache in this population.

Originalsprog	Engelsk
Tidsskrift	Cephalalgia
Vol/bind	30
Udgave nummer	9
Sider (fra-til)	1041-8
Antal sider	8
ISSN	0333-1024
DOI	https://doi.org/10.1177/0333102409359091
Status	Udgivet - 1 sep. 2010

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10.1177/0333102409359091

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AB - INTRODUCTION: Specific problems occur in clinical treatment trials for migraine with aura that differ from those encountered in treatment trials for migraine without aura. DISCUSSION: Based on our experience with four such trials, we point to a number of possible solutions and outline areas for future inquiry. We make recommendations about subject selection; the choice, definition and assessment of outcome measures; optimal treatments in relation to aura and headache; and we provide samples of study report forms used to record occurrence of aura and headache in this population.

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On the methodology of drug trials in migraine with aura

Abstract

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