Nutritional status and long-term mortality in hospitalised patients with chronic obstructive pulmonary disease (COPD).

Runa Hallin; Gunnar Gudmundsson; Charlotte Suppli Ulrik; Markku M Nieminen; Thorarinn Gislason; Eva Lindberg; Eva Brøndum; Tiina Aine; Per Bakke; Christer Janson

doi:http://dx.doi.org/10.1016/j.rmed.2007.04.009

Nutritional status and long-term mortality in hospitalised patients with chronic obstructive pulmonary disease (COPD).

Runa Hallin, Gunnar Gudmundsson, Charlotte Suppli Ulrik, Markku M Nieminen, Thorarinn Gislason, Eva Lindberg, Eva Brøndum, Tiina Aine, Per Bakke, Christer Janson

102 Citationer (Scopus)

Abstract

Patients with chronic obstructive pulmonary disease (COPD) often have difficulties with keeping their weight. The aim of this investigation was to study nutritional status in hospitalised Nordic COPD patients and to investigate the association between nutritional status and long-term mortality in this patient group. In a multicentre study conducted at four university hospitals (Reykjavik, Uppsala, Tampere and Copenhagen) hospitalised patients with COPD were investigated. Patient height, weight and lung function was recorded. Health status was assessed with St. George's Hospital Respiratory Questionnaire. After 2 years, mortality data was obtained from the national registers in each country. Of the 261 patients in the study 19% where underweight (BMI <20), 41% were of normal weight (BMI 20-25), 26% were overweight (BMI 25-30) and 14% were obese. FEV(1) was lowest in the underweight and highest in the overweight group (p=0.001) whereas the prevalence of diabetes and cardio-vascular co-morbidity went the opposite direction. Of the 261 patients 49 (19%) had died within 2 years. The lowest mortality was found among the overweight patients, whereas underweight was related to increased overall mortality. The association between underweight in COPD-patients, and mortality remained significant after adjusting for possible confounders such as FEV(1) (hazard risk ratio (95% CI) 2.6 (1.3-5.2)). We conclude that COPD patients that are underweight at admission to hospital have a higher risk of dying within the next 2 years. Further studies are needed in order to show whether identifying and treating weight loss and depletion of fat-free mass (FFM) is a way forward in improving the prognosis for hospitalised COPD patients.
Udgivelsesdato: 2007-Sep

Originalsprog	Engelsk
Tidsskrift	Respiratory Medicine
Vol/bind	101
Udgave nummer	9
Sider (fra-til)	1954-60
Antal sider	6
ISSN	0954-6111
DOI	https://doi.org/10.1016/j.rmed.2007.04.009
Status	Udgivet - 2007

Adgang til dokumentet

http://dx.doi.org/10.1016/j.rmed.2007.04.009

Citationsformater

@article{b090155b4a6b4a6dba57daf0e4423e23,

title = "Nutritional status and long-term mortality in hospitalised patients with chronic obstructive pulmonary disease (COPD).",

abstract = "Patients with chronic obstructive pulmonary disease (COPD) often have difficulties with keeping their weight. The aim of this investigation was to study nutritional status in hospitalised Nordic COPD patients and to investigate the association between nutritional status and long-term mortality in this patient group. In a multicentre study conducted at four university hospitals (Reykjavik, Uppsala, Tampere and Copenhagen) hospitalised patients with COPD were investigated. Patient height, weight and lung function was recorded. Health status was assessed with St. George's Hospital Respiratory Questionnaire. After 2 years, mortality data was obtained from the national registers in each country. Of the 261 patients in the study 19% where underweight (BMI <20), 41% were of normal weight (BMI 20-25), 26% were overweight (BMI 25-30) and 14% were obese. FEV(1) was lowest in the underweight and highest in the overweight group (p=0.001) whereas the prevalence of diabetes and cardio-vascular co-morbidity went the opposite direction. Of the 261 patients 49 (19%) had died within 2 years. The lowest mortality was found among the overweight patients, whereas underweight was related to increased overall mortality. The association between underweight in COPD-patients, and mortality remained significant after adjusting for possible confounders such as FEV(1) (hazard risk ratio (95% CI) 2.6 (1.3-5.2)). We conclude that COPD patients that are underweight at admission to hospital have a higher risk of dying within the next 2 years. Further studies are needed in order to show whether identifying and treating weight loss and depletion of fat-free mass (FFM) is a way forward in improving the prognosis for hospitalised COPD patients. Udgivelsesdato: 2007-Sep",

author = "Runa Hallin and Gunnar Gudmundsson and {Suppli Ulrik}, Charlotte and Nieminen, {Markku M} and Thorarinn Gislason and Eva Lindberg and Eva Br{\o}ndum and Tiina Aine and Per Bakke and Christer Janson",

year = "2007",

doi = "http://dx.doi.org/10.1016/j.rmed.2007.04.009",

language = "English",

volume = "101",

pages = "1954--60",

journal = "Respiratory Medicine",

issn = "0954-6111",

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number = "9",

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TY - JOUR

T1 - Nutritional status and long-term mortality in hospitalised patients with chronic obstructive pulmonary disease (COPD).

AU - Hallin, Runa

AU - Gudmundsson, Gunnar

AU - Suppli Ulrik, Charlotte

AU - Nieminen, Markku M

AU - Gislason, Thorarinn

AU - Lindberg, Eva

AU - Brøndum, Eva

AU - Aine, Tiina

AU - Bakke, Per

AU - Janson, Christer

PY - 2007

Y1 - 2007

N2 - Patients with chronic obstructive pulmonary disease (COPD) often have difficulties with keeping their weight. The aim of this investigation was to study nutritional status in hospitalised Nordic COPD patients and to investigate the association between nutritional status and long-term mortality in this patient group. In a multicentre study conducted at four university hospitals (Reykjavik, Uppsala, Tampere and Copenhagen) hospitalised patients with COPD were investigated. Patient height, weight and lung function was recorded. Health status was assessed with St. George's Hospital Respiratory Questionnaire. After 2 years, mortality data was obtained from the national registers in each country. Of the 261 patients in the study 19% where underweight (BMI <20), 41% were of normal weight (BMI 20-25), 26% were overweight (BMI 25-30) and 14% were obese. FEV(1) was lowest in the underweight and highest in the overweight group (p=0.001) whereas the prevalence of diabetes and cardio-vascular co-morbidity went the opposite direction. Of the 261 patients 49 (19%) had died within 2 years. The lowest mortality was found among the overweight patients, whereas underweight was related to increased overall mortality. The association between underweight in COPD-patients, and mortality remained significant after adjusting for possible confounders such as FEV(1) (hazard risk ratio (95% CI) 2.6 (1.3-5.2)). We conclude that COPD patients that are underweight at admission to hospital have a higher risk of dying within the next 2 years. Further studies are needed in order to show whether identifying and treating weight loss and depletion of fat-free mass (FFM) is a way forward in improving the prognosis for hospitalised COPD patients. Udgivelsesdato: 2007-Sep

AB - Patients with chronic obstructive pulmonary disease (COPD) often have difficulties with keeping their weight. The aim of this investigation was to study nutritional status in hospitalised Nordic COPD patients and to investigate the association between nutritional status and long-term mortality in this patient group. In a multicentre study conducted at four university hospitals (Reykjavik, Uppsala, Tampere and Copenhagen) hospitalised patients with COPD were investigated. Patient height, weight and lung function was recorded. Health status was assessed with St. George's Hospital Respiratory Questionnaire. After 2 years, mortality data was obtained from the national registers in each country. Of the 261 patients in the study 19% where underweight (BMI <20), 41% were of normal weight (BMI 20-25), 26% were overweight (BMI 25-30) and 14% were obese. FEV(1) was lowest in the underweight and highest in the overweight group (p=0.001) whereas the prevalence of diabetes and cardio-vascular co-morbidity went the opposite direction. Of the 261 patients 49 (19%) had died within 2 years. The lowest mortality was found among the overweight patients, whereas underweight was related to increased overall mortality. The association between underweight in COPD-patients, and mortality remained significant after adjusting for possible confounders such as FEV(1) (hazard risk ratio (95% CI) 2.6 (1.3-5.2)). We conclude that COPD patients that are underweight at admission to hospital have a higher risk of dying within the next 2 years. Further studies are needed in order to show whether identifying and treating weight loss and depletion of fat-free mass (FFM) is a way forward in improving the prognosis for hospitalised COPD patients. Udgivelsesdato: 2007-Sep

U2 - http://dx.doi.org/10.1016/j.rmed.2007.04.009

DO - http://dx.doi.org/10.1016/j.rmed.2007.04.009

M3 - Journal article

SN - 0954-6111

VL - 101

SP - 1954

EP - 1960

JO - Respiratory Medicine

JF - Respiratory Medicine

IS - 9

ER -