NT-ProBNP Independently Predicts Long-Term Mortality in Patients Admitted for Coronary Angiography

TY - JOUR

T1 - NT-ProBNP Independently Predicts Long-Term Mortality in Patients Admitted for Coronary Angiography

AU - Ruwald, Martin Huth

AU - Goetze, Jens Peter

AU - Bech, Jan

AU - Nielsen, Olav Wendelboe

AU - Madsen, Bente Kühn

AU - Nielsen, Lars Bo

AU - Mouridsen, Mette

AU - Ruwald, Anne-Christine Huth

AU - Madsen, Jan Kyst

AU - Pedersen, Sune

PY - 2014/1

Y1 - 2014/1

N2 - Recently, research interests are focussed on biomarkers to predict the outcome in patients with coronary artery disease (CAD). We examined whether the levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) could predict outcome in patients who underwent elective or acute coronary angiography (CAG). A total of 337 patients with suspected CAD who underwent elective or acute CAG were followed up for a mean period of 6.7 years. Primary end points were all-cause mortality (ACM) and the combined end point of ACM, nonfatal myocardial infarction, and revascularization. In all, 53 (16%) patients died and 88 (26%) patients reached the combined end point. Preprocedural NT-proBNP above 32 pmol/L independently predicted ACM (hazard ratio [HR] 3.11; confidence interval [CI]: 1.60-6.07; P = .001) and the combined end point (HR 2.44 [CI: 1.50-3.97]; P < .001). This study indicates that high NT-proBNP is an independent predictor of ACM on long-term follow-up. N-terminal-proBNP is a reliable predictive marker of mortality in the setting of stable or unstable angina.

AB - Recently, research interests are focussed on biomarkers to predict the outcome in patients with coronary artery disease (CAD). We examined whether the levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) could predict outcome in patients who underwent elective or acute coronary angiography (CAG). A total of 337 patients with suspected CAD who underwent elective or acute CAG were followed up for a mean period of 6.7 years. Primary end points were all-cause mortality (ACM) and the combined end point of ACM, nonfatal myocardial infarction, and revascularization. In all, 53 (16%) patients died and 88 (26%) patients reached the combined end point. Preprocedural NT-proBNP above 32 pmol/L independently predicted ACM (hazard ratio [HR] 3.11; confidence interval [CI]: 1.60-6.07; P = .001) and the combined end point (HR 2.44 [CI: 1.50-3.97]; P < .001). This study indicates that high NT-proBNP is an independent predictor of ACM on long-term follow-up. N-terminal-proBNP is a reliable predictive marker of mortality in the setting of stable or unstable angina.

KW - Aged

KW - Biological Markers

KW - Coronary Angiography

KW - Coronary Artery Disease

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Natriuretic Peptide, Brain

KW - Peptide Fragments

KW - Prognosis

KW - Survival Rate

U2 - 10.1177/0003319712462758

DO - 10.1177/0003319712462758

M3 - Journal article

C2 - 23070682

SN - 0003-3197

VL - 65

SP - 31

EP - 36

JO - Angiology

JF - Angiology

IS - 1

ER -