Novel variant of CYP2D6*6 is undetected by a commonly used genotyping procedure

TY - JOUR

T1 - Novel variant of CYP2D6*6 is undetected by a commonly used genotyping procedure

AU - Rasmussen, Henrik Berg

AU - Werge, Thomas

PY - 2011

Y1 - 2011

N2 - We report the identification of a novel and defective variant of the gene encoding cytochrome P450 2D6 (CYP2D6). This novel variant is a subtype of CYP2D6*6 that was undetected by a commercially available 5' exonuclease-based assay. Because the novel variant was found in only one of 609 individuals, it represents a rare subtype of CYP2D6*6 that may be restricted to a single family or a subpopulation. A procedure for the identification of the novel CYP2D6*6 variant using restriction enzyme treatment of amplified fragments was developed.

AB - We report the identification of a novel and defective variant of the gene encoding cytochrome P450 2D6 (CYP2D6). This novel variant is a subtype of CYP2D6*6 that was undetected by a commercially available 5' exonuclease-based assay. Because the novel variant was found in only one of 609 individuals, it represents a rare subtype of CYP2D6*6 that may be restricted to a single family or a subpopulation. A procedure for the identification of the novel CYP2D6*6 variant using restriction enzyme treatment of amplified fragments was developed.

M3 - Journal article

SN - 1734-1140

VL - 63

SP - 1264

EP - 1266

JO - Pharmacological Reports

JF - Pharmacological Reports

IS - 5

ER -