Novel Plasmodium falciparum malaria vaccines: evidence-based searching for variant surface antigens as candidates for vaccination against pregnancy-associated malaria

TY - JOUR

T1 - Novel Plasmodium falciparum malaria vaccines: evidence-based searching for variant surface antigens as candidates for vaccination against pregnancy-associated malaria

AU - Staalsoe, Trine

AU - Jensen, Anja T R

AU - Theander, Thor G

AU - Hviid, Lars

N1 - Keywords: Animals; Antigens, Surface; Chondroitin Sulfates; Evidence-Based Medicine; Female; Humans; Malaria Vaccines; Malaria, Falciparum; Plasmodium falciparum; Pregnancy; Pregnancy Complications, Parasitic

PY - 2002

Y1 - 2002

N2 - Malaria vaccine development has traditionally concentrated on careful molecular, biochemical, and immunological characterisation of candidate antigens. In contrast, evidence of the importance of identified antigens in immunity to human infection and disease has generally been limited to statistically significant co-variation with protection rather than on demonstration of causal relationships. We have studied the relationship between variant surface antigen-specific antibodies and clinical protection from Plasmodium falciparum malaria in general, and from pregnancy-associated malaria (PAM) in particular, to provide robust evidence of a causal link between the two in order to allow efficient and evidence-based identification of candidate antigens for malaria vaccine development.

AB - Malaria vaccine development has traditionally concentrated on careful molecular, biochemical, and immunological characterisation of candidate antigens. In contrast, evidence of the importance of identified antigens in immunity to human infection and disease has generally been limited to statistically significant co-variation with protection rather than on demonstration of causal relationships. We have studied the relationship between variant surface antigen-specific antibodies and clinical protection from Plasmodium falciparum malaria in general, and from pregnancy-associated malaria (PAM) in particular, to provide robust evidence of a causal link between the two in order to allow efficient and evidence-based identification of candidate antigens for malaria vaccine development.

M3 - Journal article

C2 - 12270550

SN - 0165-2478

VL - 84

SP - 133

EP - 136

JO - Immunology Letters

JF - Immunology Letters

IS - 2

ER -