@article{1183ced1ea714dd7a89b4fe7848a7ce2,
title = "Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands",
abstract = "Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles are synthesized using a six-step protocol. Notably, the synthesis route make use of a new and improved ring-closing methodology for the assembly of the hexahydro-pyrazino[1,2-a]indole scaffold, which is based on intramolecular C-H insertion of a carbene. The compounds act as dual serotonin 5-HT2C- and 5-HT6-ligands.",
keywords = "Cell Line, Hela Cells, Humans, Indoles, Ligands, Protein Binding, Pyrazines, Receptor, Serotonin, 5-HT2C, Receptors, Serotonin, Structure-Activity Relationship, Former Faculty of Pharmaceutical Sciences",
author = "Niels Krogsgaard-Larsen and Jensen, {Anders A.} and Jan Kehler",
note = "Keywords: carbene, C-H insertion, serotonin, 5-HT2C, 5-HT6, 1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indole",
year = "2010",
month = sep,
day = "15",
doi = "10.1016/j.bmcl.2010.07.105",
language = "English",
volume = "20",
pages = "5431--5433",
journal = "Bioorganic & Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Pergamon Press",
number = "18",
}