Normal tension glaucoma and Alzheimer disease: comorbidity?

TY - JOUR

T1 - Normal tension glaucoma and Alzheimer disease

T2 - comorbidity?

AU - Bach-Holm, Daniella

AU - Kessing, Svend Vedel

AU - Mogensen, Ulla Brasch

AU - Forman, Julie Lyng

AU - Andersen, Per Kragh

AU - Kessing, Lars Vedel

N1 - © 2011 The Authors. Acta Ophthalmologica © 2011 Acta Ophthalmologica Scandinavica Foundation.

PY - 2012/11

Y1 - 2012/11

N2 - Purpose: To investigate whether normal tension glaucoma (NTG) is associated with increased risk of developing dementia/Alzheimer disease (AD). Methods: A total of 69 patients with NTG were identified in the case note files in the Glaucoma Clinic, University Hospital of Copenhagen (Rigshospitalet), Denmark from 1980 to 2001. The rate of a subsequent diagnosis of dementia as recorded in nationwide health care registers from 1980 to 2005 was estimated and compared with the rate for the general population [standard mortality rate (SMR) = observed number of cases of dementia/expected number of cases of dementia]. Results: The 69 patients had a median age of 64 years (quartiles 57 and 73) at the time of the diagnosis, and the average follow-up period was 12.7 years. The SMR(dementia) was 0.20 (95% CI 0.01-1.11). No patient developed AD. Conclusion: Normal tension glaucoma was not associated with an increased risk of developing dementia/AD.

AB - Purpose: To investigate whether normal tension glaucoma (NTG) is associated with increased risk of developing dementia/Alzheimer disease (AD). Methods: A total of 69 patients with NTG were identified in the case note files in the Glaucoma Clinic, University Hospital of Copenhagen (Rigshospitalet), Denmark from 1980 to 2001. The rate of a subsequent diagnosis of dementia as recorded in nationwide health care registers from 1980 to 2005 was estimated and compared with the rate for the general population [standard mortality rate (SMR) = observed number of cases of dementia/expected number of cases of dementia]. Results: The 69 patients had a median age of 64 years (quartiles 57 and 73) at the time of the diagnosis, and the average follow-up period was 12.7 years. The SMR(dementia) was 0.20 (95% CI 0.01-1.11). No patient developed AD. Conclusion: Normal tension glaucoma was not associated with an increased risk of developing dementia/AD.

U2 - 10.1111/j.1755-3768.2011.02125.x

DO - 10.1111/j.1755-3768.2011.02125.x

M3 - Journal article

C2 - 21332678

SN - 1755-375X

VL - 89

SP - 1

EP - 3

JO - Acta Ophthalmologica

JF - Acta Ophthalmologica

ER -