Normal Tempo of Bone Formation in Turner Syndrome despite Signs of Accelerated Bone Resorption

Line Cleemann; Kirsten Holm; Hanne Kobbernagel; Sven O Skouby; Bent Kristensen; Heidi Smedegaard; Anna-Maria Andersson; Arieh Cohen; Claus Højbjerg Gravholt

doi:10.1159/000329046

Normal Tempo of Bone Formation in Turner Syndrome despite Signs of Accelerated Bone Resorption

Line Cleemann, Kirsten Holm, Hanne Kobbernagel, Sven O Skouby, Bent Kristensen, Heidi Smedegaard, Anna-Maria Andersson, Arieh Cohen, Claus Højbjerg Gravholt

10 Citationer (Scopus)

Abstract

Aims: To evaluate area bone mineral density (aBMD) and volumetric BMD (vBMD) by dual-energy X-ray absorptiometry, and relations to bone markers and hormones in adolescent women with Turner syndrome (TS). Methods: Cross-sectional study in TS patients (n = 37, 16.7 ± 3.4 years) and control group (n = 49), assessed by dual-energy X-ray absorptiometry, bone markers and hormones. TS patients were divided into a young group receiving ('ongoing') GH (n = 15) and an older group previously receiving ('previous') GH (n = 22). Results: vBMD(spine) was similar in 'ongoing GH' TS, but higher in 'previous GH' TS, compared to controls. vBMD(hip) was lower in 'ongoing GH' TS, but similar in 'previous GH'. z scores for aBMD were uniformly reduced in 'ongoing TS', but near-normalized in 'previous GH' TS. Bone formation and resorption markers were increased in 'ongoing GH' TS, while 'previous GH' TS had elevated bone resorption markers. Conclusion: BMD increased in parallel with age in TS patients receiving optimal estradiol replacement therapy and GH according to consensus guidelines, and in controls. Young TS undergoing pubertal induction and still receiving GH have lower z score BMD than older TS patients receiving hormonal replacement therapy, where a near-normalization of BMD was achieved. TS patients previously receiving GH showed signs of increased bone resorption.

Originalsprog	Engelsk
Tidsskrift	Hormone Research in Paediatrics
Vol/bind	76
Udgave nummer	3
Sider (fra-til)	193-201
Antal sider	9
ISSN	1663-2818
DOI	https://doi.org/10.1159/000329046
Status	Udgivet - okt. 2011

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10.1159/000329046

Citationsformater

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title = "Normal Tempo of Bone Formation in Turner Syndrome despite Signs of Accelerated Bone Resorption",

abstract = "Aims: To evaluate area bone mineral density (aBMD) and volumetric BMD (vBMD) by dual-energy X-ray absorptiometry, and relations to bone markers and hormones in adolescent women with Turner syndrome (TS). Methods: Cross-sectional study in TS patients (n = 37, 16.7 ± 3.4 years) and control group (n = 49), assessed by dual-energy X-ray absorptiometry, bone markers and hormones. TS patients were divided into a young group receiving ('ongoing') GH (n = 15) and an older group previously receiving ('previous') GH (n = 22). Results: vBMD(spine) was similar in 'ongoing GH' TS, but higher in 'previous GH' TS, compared to controls. vBMD(hip) was lower in 'ongoing GH' TS, but similar in 'previous GH'. z scores for aBMD were uniformly reduced in 'ongoing TS', but near-normalized in 'previous GH' TS. Bone formation and resorption markers were increased in 'ongoing GH' TS, while 'previous GH' TS had elevated bone resorption markers. Conclusion: BMD increased in parallel with age in TS patients receiving optimal estradiol replacement therapy and GH according to consensus guidelines, and in controls. Young TS undergoing pubertal induction and still receiving GH have lower z score BMD than older TS patients receiving hormonal replacement therapy, where a near-normalization of BMD was achieved. TS patients previously receiving GH showed signs of increased bone resorption.",

author = "Line Cleemann and Kirsten Holm and Hanne Kobbernagel and Skouby, {Sven O} and Bent Kristensen and Heidi Smedegaard and Anna-Maria Andersson and Arieh Cohen and Gravholt, {Claus H{\o}jbjerg}",

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year = "2011",

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doi = "10.1159/000329046",

language = "English",

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pages = "193--201",

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issn = "1663-2818",

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TY - JOUR

T1 - Normal Tempo of Bone Formation in Turner Syndrome despite Signs of Accelerated Bone Resorption

AU - Cleemann, Line

AU - Holm, Kirsten

AU - Kobbernagel, Hanne

AU - Skouby, Sven O

AU - Kristensen, Bent

AU - Smedegaard, Heidi

AU - Andersson, Anna-Maria

AU - Cohen, Arieh

AU - Gravholt, Claus Højbjerg

PY - 2011/10

Y1 - 2011/10

N2 - Aims: To evaluate area bone mineral density (aBMD) and volumetric BMD (vBMD) by dual-energy X-ray absorptiometry, and relations to bone markers and hormones in adolescent women with Turner syndrome (TS). Methods: Cross-sectional study in TS patients (n = 37, 16.7 ± 3.4 years) and control group (n = 49), assessed by dual-energy X-ray absorptiometry, bone markers and hormones. TS patients were divided into a young group receiving ('ongoing') GH (n = 15) and an older group previously receiving ('previous') GH (n = 22). Results: vBMD(spine) was similar in 'ongoing GH' TS, but higher in 'previous GH' TS, compared to controls. vBMD(hip) was lower in 'ongoing GH' TS, but similar in 'previous GH'. z scores for aBMD were uniformly reduced in 'ongoing TS', but near-normalized in 'previous GH' TS. Bone formation and resorption markers were increased in 'ongoing GH' TS, while 'previous GH' TS had elevated bone resorption markers. Conclusion: BMD increased in parallel with age in TS patients receiving optimal estradiol replacement therapy and GH according to consensus guidelines, and in controls. Young TS undergoing pubertal induction and still receiving GH have lower z score BMD than older TS patients receiving hormonal replacement therapy, where a near-normalization of BMD was achieved. TS patients previously receiving GH showed signs of increased bone resorption.

AB - Aims: To evaluate area bone mineral density (aBMD) and volumetric BMD (vBMD) by dual-energy X-ray absorptiometry, and relations to bone markers and hormones in adolescent women with Turner syndrome (TS). Methods: Cross-sectional study in TS patients (n = 37, 16.7 ± 3.4 years) and control group (n = 49), assessed by dual-energy X-ray absorptiometry, bone markers and hormones. TS patients were divided into a young group receiving ('ongoing') GH (n = 15) and an older group previously receiving ('previous') GH (n = 22). Results: vBMD(spine) was similar in 'ongoing GH' TS, but higher in 'previous GH' TS, compared to controls. vBMD(hip) was lower in 'ongoing GH' TS, but similar in 'previous GH'. z scores for aBMD were uniformly reduced in 'ongoing TS', but near-normalized in 'previous GH' TS. Bone formation and resorption markers were increased in 'ongoing GH' TS, while 'previous GH' TS had elevated bone resorption markers. Conclusion: BMD increased in parallel with age in TS patients receiving optimal estradiol replacement therapy and GH according to consensus guidelines, and in controls. Young TS undergoing pubertal induction and still receiving GH have lower z score BMD than older TS patients receiving hormonal replacement therapy, where a near-normalization of BMD was achieved. TS patients previously receiving GH showed signs of increased bone resorption.

U2 - 10.1159/000329046

DO - 10.1159/000329046

M3 - Journal article

SN - 1663-2818

VL - 76

SP - 193

EP - 201

JO - Hormone Research in Paediatrics

JF - Hormone Research in Paediatrics

IS - 3

ER -

Normal Tempo of Bone Formation in Turner Syndrome despite Signs of Accelerated Bone Resorption

Abstract

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