Non-pharmacological modulation of cerebral white matter organization: A systematic review of non-psychiatric and psychiatric studies

TY - JOUR

T1 - Non-pharmacological modulation of cerebral white matter organization

T2 - A systematic review of non-psychiatric and psychiatric studies

AU - Kristensen, Tina D

AU - Mandl, Rene C W

AU - Jepsen, Jens R M

AU - Rostrup, Egill

AU - Glenthøj, Louise B

AU - Nordentoft, Merete

AU - Glenthøj, Birte Y

AU - Ebdrup, Bjørn H

N1 - Copyright © 2018 Elsevier Ltd. All rights reserved.

PY - 2018/5

Y1 - 2018/5

N2 - OBJECTIVE: Neuroplasticity is a well-described phenomenon, but effects of non-pharmacological interventions on white matter (WM) are unclear. Here we review associations between active non-pharmacological interventions and WM organization in healthy subjects and in psychiatric patients.METHOD: A systematic review of non-psychiatric and psychiatric studies in MEDLINE and EMBASE databases. We included longitudinal, controlled studies in human participants aged 18-60 years published in peer-reviewed journals between 2000 and 2017. Studies required active interventions lasting between one day and one year, targeting cognitive-, motor- or sensory domains. The primary outcome was intervention-related brain changes in diffusion-weighted imaging (DWI) derived measures.RESULTS: We included 25 studies. Twenty studies reported positive findings. Five studies investigated psychiatric patients. Nine randomized, controlled trials (RCTs) reported DWI changes following cognitive interventions. Interventions were too heterogeneous to perform a meta-analysis. Intervention duration of at least eight weeks appeared required to induce consistent WM changes.CONCLUSIONS: Non-pharmacological interventions can induce changes in WM. DWI is a relevant correlate of e.g. cognitive training in prospective, long-term RCTs of psychiatric patients.

AB - OBJECTIVE: Neuroplasticity is a well-described phenomenon, but effects of non-pharmacological interventions on white matter (WM) are unclear. Here we review associations between active non-pharmacological interventions and WM organization in healthy subjects and in psychiatric patients.METHOD: A systematic review of non-psychiatric and psychiatric studies in MEDLINE and EMBASE databases. We included longitudinal, controlled studies in human participants aged 18-60 years published in peer-reviewed journals between 2000 and 2017. Studies required active interventions lasting between one day and one year, targeting cognitive-, motor- or sensory domains. The primary outcome was intervention-related brain changes in diffusion-weighted imaging (DWI) derived measures.RESULTS: We included 25 studies. Twenty studies reported positive findings. Five studies investigated psychiatric patients. Nine randomized, controlled trials (RCTs) reported DWI changes following cognitive interventions. Interventions were too heterogeneous to perform a meta-analysis. Intervention duration of at least eight weeks appeared required to induce consistent WM changes.CONCLUSIONS: Non-pharmacological interventions can induce changes in WM. DWI is a relevant correlate of e.g. cognitive training in prospective, long-term RCTs of psychiatric patients.

U2 - 10.1016/j.neubiorev.2018.03.013

DO - 10.1016/j.neubiorev.2018.03.013

M3 - Review

C2 - 29550210

SN - 0149-7634

VL - 88

SP - 84

EP - 97

JO - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

ER -