Non-lymphoma hematological malignancies in systemic lupus erythematosus

TY - JOUR

T1 - Non-lymphoma hematological malignancies in systemic lupus erythematosus

AU - Lu, Mary

AU - Bernatsky, Sasha

AU - Ramsey-Goldman, Rosalind

AU - Petri, Michelle

AU - Manzi, Susan

AU - Urowitz, Murray B

AU - Gladman, Dafna

AU - Fortin, Paul R

AU - Ginzler, Ellen M

AU - Yelin, Edward

AU - Bae, Sang-Cheol

AU - Wallace, Daniel J

AU - Jacobsen, Soren

AU - Dooley, Mary Anne

AU - Peschken, Christine A

AU - Alarc�n, Graciela S

AU - Nived, Ola

AU - Gottesman, Lena

AU - Criswell, Lindsey A

AU - Sturfelt, Gunnar

AU - Dreyer, Lene

AU - Lee, Jennifer L

AU - Clarke, Ann E

PY - 2013/11

Y1 - 2013/11

N2 - Objective: To describe non-lymphoma hematological malignancies in systemic lupus erythematosus (SLE). Methods: A large SLE cohort was linked to cancer registries. We examined the types of non-lymphoma hematological cancers. Results: In 16,409 patients, 115 hematological cancers [including myelodysplastic syndrome (MDS)] occurred. Among these, 33 were non-lymphoma. Of the 33 non-lymphoma cases, 13 were of lymphoid lineage: multiple myeloma (n = 5), plasmacytoma (n = 3), B cell chronic lymphocytic leukemia (B-CLL; n = 3), precursor cell lymphoblastic leukemia (n = 1) and unspecified lymphoid leukemia (n = 1). The remaining 20 cases were of myeloid lineage: MDS (n = 7), acute myeloid leukemia (AML; n = 7), chronic myeloid leukemia (CML; n = 2) and 4 unspecified leukemias. Most of these malignancies occurred in female Caucasians, except for plasma cell neoplasms (4/5 multiple myeloma and 1/3 plasmacytoma cases occurred in blacks). Conclusions: In this large SLE cohort, the most common non-lymphoma hematological malignancies were myeloid types (MDS and AML). This is in contrast to the general population, where lymphoid types are 1.7 times more common than myeloid non-lymphoma hematological malignancies. Most (80%) multiple myeloma cases occurred in blacks; this requires further investigation.

AB - Objective: To describe non-lymphoma hematological malignancies in systemic lupus erythematosus (SLE). Methods: A large SLE cohort was linked to cancer registries. We examined the types of non-lymphoma hematological cancers. Results: In 16,409 patients, 115 hematological cancers [including myelodysplastic syndrome (MDS)] occurred. Among these, 33 were non-lymphoma. Of the 33 non-lymphoma cases, 13 were of lymphoid lineage: multiple myeloma (n = 5), plasmacytoma (n = 3), B cell chronic lymphocytic leukemia (B-CLL; n = 3), precursor cell lymphoblastic leukemia (n = 1) and unspecified lymphoid leukemia (n = 1). The remaining 20 cases were of myeloid lineage: MDS (n = 7), acute myeloid leukemia (AML; n = 7), chronic myeloid leukemia (CML; n = 2) and 4 unspecified leukemias. Most of these malignancies occurred in female Caucasians, except for plasma cell neoplasms (4/5 multiple myeloma and 1/3 plasmacytoma cases occurred in blacks). Conclusions: In this large SLE cohort, the most common non-lymphoma hematological malignancies were myeloid types (MDS and AML). This is in contrast to the general population, where lymphoid types are 1.7 times more common than myeloid non-lymphoma hematological malignancies. Most (80%) multiple myeloma cases occurred in blacks; this requires further investigation.

U2 - 10.1159/000350165

DO - 10.1159/000350165

M3 - Journal article

C2 - 24107608

SN - 0030-2414

VL - 85

SP - 235

EP - 240

JO - Oncology

JF - Oncology

IS - 4

ER -