Non-endocannabinoid N-Acylethanolamines and Monoacylglycerols: Old Molecules New Targets

Harald S. Hansen; Karen Kleberg; Helle Adser Hassing

Non-endocannabinoid N-Acylethanolamines and Monoacylglycerols: Old Molecules New Targets

Harald S. Hansen, Karen Kleberg, Helle Adser Hassing

2 Citationer (Scopus)

Abstract

N-Acylethanolamine (NAE) and 2-monoacylglycerol (2-MAG) containing arachidonic acid are being called endocannabinoids since they can activate cannabinoid receptors. The same molecules containing stearic acid, palmitic acid, oleic acid, or linoleic acid cannot activate cannabinoid receptors, and are thus called non-endocannabinoid NAEs and 2-MAGs. However, these molecules do also have biological activities, e.g., via activation of the transcription factor PPARα, which mediate anti-inflammatory, antinociceptive, and anorectic effects. Furthermore, activation of the G-protein coupled receptor GPR119 in the small intestine could mediate release of the incretin hormone GLP-1. The present chapter describes the formation and degradation of these lipid molecules, as well as their pharmacology and their related drug targets.

Originalsprog	Dansk
Titel	The Endocannabinoidome : The World of Endocannabinoids and Related Mediators
Redaktører	Vincenzo Di Marzo, Jenny Wang
Antal sider	13
Vol/bind	Elsevier
Udgivelsessted	Amsterdam
Publikationsdato	2015
Sider	1-13
Kapitel	1
ISBN (Trykt)	978-0-12-420126-2
Status	Udgivet - 2015

Emneord

Det Sundhedsvidenskabelige Fakultet
Endocannabinoids
anandamide
oleoylethanolamide
palmitoylethanolamide
gpr119
2-oleoyl glycerol
monoacylglycerol
N-acylethanolamine
dietary fat
GLP-1
PPAR alpha
Appetite Regulation
Intestinal Absorption
Intestinal Mucosa
Lipoprotein Lipase
2-arachidonoyl glycerol
monoacylglycerol acyltransferase

Andre filer og links

https://www.elsevier.com/books/the-endocannabinoidome/di-marzo/978-0-12-420126-2

Citationsformater

Non-endocannabinoid N-Acylethanolamines and Monoacylglycerols: Old Molecules New Targets. / Hansen, Harald S.; Kleberg, Karen; Hassing, Helle Adser.
The Endocannabinoidome: The World of Endocannabinoids and Related Mediators. red. / Vincenzo Di Marzo; Jenny Wang. Bind Elsevier Amsterdam, 2015. s. 1-13.

Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › peer review

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title = "Non-endocannabinoid N-Acylethanolamines and Monoacylglycerols: Old Molecules New Targets",

abstract = "N-Acylethanolamine (NAE) and 2-monoacylglycerol (2-MAG) containing arachidonic acid are being called endocannabinoids since they can activate cannabinoid receptors. The same molecules containing stearic acid, palmitic acid, oleic acid, or linoleic acid cannot activate cannabinoid receptors, and are thus called non-endocannabinoid NAEs and 2-MAGs. However, these molecules do also have biological activities, e.g., via activation of the transcription factor PPARα, which mediate anti-inflammatory, antinociceptive, and anorectic effects. Furthermore, activation of the G-protein coupled receptor GPR119 in the small intestine could mediate release of the incretin hormone GLP-1. The present chapter describes the formation and degradation of these lipid molecules, as well as their pharmacology and their related drug targets.",

keywords = "Det Sundhedsvidenskabelige Fakultet, Endocannabinoids, anandamide, oleoylethanolamide, palmitoylethanolamide, gpr119, 2-oleoyl glycerol, monoacylglycerol, N-acylethanolamine, dietary fat, GLP-1, PPAR alpha, Appetite Regulation, Intestinal Absorption, Intestinal Mucosa, Lipoprotein Lipase, 2-arachidonoyl glycerol, monoacylglycerol acyltransferase",

author = "Hansen, {Harald S.} and Karen Kleberg and Hassing, {Helle Adser}",

year = "2015",

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isbn = "978-0-12-420126-2",

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T1 - Non-endocannabinoid N-Acylethanolamines and Monoacylglycerols: Old Molecules New Targets

AU - Hansen, Harald S.

AU - Kleberg, Karen

AU - Hassing, Helle Adser

PY - 2015

Y1 - 2015

N2 - N-Acylethanolamine (NAE) and 2-monoacylglycerol (2-MAG) containing arachidonic acid are being called endocannabinoids since they can activate cannabinoid receptors. The same molecules containing stearic acid, palmitic acid, oleic acid, or linoleic acid cannot activate cannabinoid receptors, and are thus called non-endocannabinoid NAEs and 2-MAGs. However, these molecules do also have biological activities, e.g., via activation of the transcription factor PPARα, which mediate anti-inflammatory, antinociceptive, and anorectic effects. Furthermore, activation of the G-protein coupled receptor GPR119 in the small intestine could mediate release of the incretin hormone GLP-1. The present chapter describes the formation and degradation of these lipid molecules, as well as their pharmacology and their related drug targets.

AB - N-Acylethanolamine (NAE) and 2-monoacylglycerol (2-MAG) containing arachidonic acid are being called endocannabinoids since they can activate cannabinoid receptors. The same molecules containing stearic acid, palmitic acid, oleic acid, or linoleic acid cannot activate cannabinoid receptors, and are thus called non-endocannabinoid NAEs and 2-MAGs. However, these molecules do also have biological activities, e.g., via activation of the transcription factor PPARα, which mediate anti-inflammatory, antinociceptive, and anorectic effects. Furthermore, activation of the G-protein coupled receptor GPR119 in the small intestine could mediate release of the incretin hormone GLP-1. The present chapter describes the formation and degradation of these lipid molecules, as well as their pharmacology and their related drug targets.

KW - Det Sundhedsvidenskabelige Fakultet

KW - Endocannabinoids

KW - anandamide

KW - oleoylethanolamide

KW - palmitoylethanolamide

KW - gpr119

KW - 2-oleoyl glycerol

KW - monoacylglycerol

KW - N-acylethanolamine

KW - dietary fat

KW - GLP-1

KW - PPAR alpha

KW - Appetite Regulation

KW - Intestinal Absorption

KW - Intestinal Mucosa

KW - Lipoprotein Lipase

KW - 2-arachidonoyl glycerol

KW - monoacylglycerol acyltransferase

UR - https://www.elsevier.com/books/the-endocannabinoidome/di-marzo/978-0-12-420126-2

M3 - Bidrag til bog/antologi

SN - 978-0-12-420126-2

VL - Elsevier

SP - 1

EP - 13

BT - The Endocannabinoidome

A2 - Di Marzo, Vincenzo

A2 - Wang, Jenny

CY - Amsterdam

ER -