No gender differences in prognosis and preventive treatment in patients with AMI without significant stenoses

Kim Hansen; Anders Hvelplund; Steen Zabell Abildstrøm; Eva Prescott; Mette Madsen; Jan Kyst Madsen; Jan Skov Jensen; Leif Thuesen; Per Thayssen; Hans Henrik Tilsted; Erik Jørgensen; Søren Galatius

doi:10.1177/1741826711416046

No gender differences in prognosis and preventive treatment in patients with AMI without significant stenoses

Kim Hansen, Anders Hvelplund, Steen Zabell Abildstrøm, Eva Prescott, Mette Madsen, Jan Kyst Madsen, Jan Skov Jensen, Leif Thuesen, Per Thayssen, Hans Henrik Tilsted, Erik Jørgensen, Søren Galatius

7 Citationer (Scopus)

Abstract

Objective: To investigate possible gender differences in patients with acute myocardial infarction (AMI) and without significant stenoses on coronary angiography (CAG) regarding prognosis and use of secondary preventive medication. Design: Nationwide register-based cohort study. Patients: By compiling data from Danish registries, we identified 20,800 patients hospitalized with AMI during 2005-2007. We included the 834 women and 761 men without significant stenoses on CAG who were discharged and alive after 60 days. Main outcome measures: All-cause mortality, recurrent AMI, and redeeming a prescription for a lipid-lowering drug, beta-blocker, clopidogrel, or aspirin within 60 days of discharge. Results: During follow-up, 97 women and 60 men died, resulting in a crude female/male hazard ratio (HR) of 1.51 (95% CI 1.09-2.08). After adjustment for age, time-period, and comorbidity, the gender difference was attenuated (HR 1.22, 95% CI 0.86-1.72). AMI recurrence was experienced by 28 women and 29 men with a female/male HR 0.88 (95% CI 0.52-1.48). After multivariable adjustment results were similar (HR 0.84, 95% CI 0.50-1.43). More women than men redeemed a prescription for lipid-lowering drugs with no differences in other medication. In the adjusted models lipid-lowering drugs, beta-blockers, clopidogrel, and aspirin were all redeemed equally with odds ratio (OR) 1.25 (95% CI 0.99-1.59), OR 1.10 (95% CI 0.88-1.37), OR 1.09 (95% CI 0.88-1.34), and OR 1.13 (95% CI 0.90-1.42), respectively. Conclusion: Our study shows that in a population of patients with a first admission for AMI and no significant stenoses on CAG, women share the same prospects as men regarding long-term prognosis and the extent of secondary preventive medical treatment.

Originalsprog	Engelsk
Tidsskrift	European Journal of Cardiovascular Prevention & Rehabilitation
Vol/bind	19
Udgave nummer	4
Sider (fra-til)	746-54
Antal sider	8
ISSN	1741-8267
DOI	https://doi.org/10.1177/1741826711416046
Status	Udgivet - aug. 2012

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10.1177/1741826711416046

https://academic.oup.com/eurjpc/article-pdf/19/4/746/34290880/eurjpc0746.pdf

Citationsformater

Hansen, K., Hvelplund, A., Abildstrøm, S. Z., Prescott, E., Madsen, M., Madsen, J. K., Jensen, J. S., Thuesen, L., Thayssen, P., Tilsted, H. H., Jørgensen, E., & Galatius, S. (2012). No gender differences in prognosis and preventive treatment in patients with AMI without significant stenoses. European Journal of Cardiovascular Prevention & Rehabilitation, 19(4), 746-54. https://doi.org/10.1177/1741826711416046

Hansen, K, Hvelplund, A, Abildstrøm, SZ, Prescott, E , Madsen, M, Madsen, JK, Jensen, JS, Thuesen, L, Thayssen, P, Tilsted, HH, Jørgensen, E & Galatius, S 2012, 'No gender differences in prognosis and preventive treatment in patients with AMI without significant stenoses', European Journal of Cardiovascular Prevention & Rehabilitation, bind 19, nr. 4, s. 746-54. https://doi.org/10.1177/1741826711416046

@article{f0df97d3fc524b56b6cc53575b776572,

title = "No gender differences in prognosis and preventive treatment in patients with AMI without significant stenoses",

abstract = "Objective: To investigate possible gender differences in patients with acute myocardial infarction (AMI) and without significant stenoses on coronary angiography (CAG) regarding prognosis and use of secondary preventive medication. Design: Nationwide register-based cohort study. Patients: By compiling data from Danish registries, we identified 20,800 patients hospitalized with AMI during 2005-2007. We included the 834 women and 761 men without significant stenoses on CAG who were discharged and alive after 60 days. Main outcome measures: All-cause mortality, recurrent AMI, and redeeming a prescription for a lipid-lowering drug, beta-blocker, clopidogrel, or aspirin within 60 days of discharge. Results: During follow-up, 97 women and 60 men died, resulting in a crude female/male hazard ratio (HR) of 1.51 (95% CI 1.09-2.08). After adjustment for age, time-period, and comorbidity, the gender difference was attenuated (HR 1.22, 95% CI 0.86-1.72). AMI recurrence was experienced by 28 women and 29 men with a female/male HR 0.88 (95% CI 0.52-1.48). After multivariable adjustment results were similar (HR 0.84, 95% CI 0.50-1.43). More women than men redeemed a prescription for lipid-lowering drugs with no differences in other medication. In the adjusted models lipid-lowering drugs, beta-blockers, clopidogrel, and aspirin were all redeemed equally with odds ratio (OR) 1.25 (95% CI 0.99-1.59), OR 1.10 (95% CI 0.88-1.37), OR 1.09 (95% CI 0.88-1.34), and OR 1.13 (95% CI 0.90-1.42), respectively. Conclusion: Our study shows that in a population of patients with a first admission for AMI and no significant stenoses on CAG, women share the same prospects as men regarding long-term prognosis and the extent of secondary preventive medical treatment.",

author = "Kim Hansen and Anders Hvelplund and Abildstr{\o}m, {Steen Zabell} and Eva Prescott and Mette Madsen and Madsen, {Jan Kyst} and Jensen, {Jan Skov} and Leif Thuesen and Per Thayssen and Tilsted, {Hans Henrik} and Erik J{\o}rgensen and S{\o}ren Galatius",

year = "2012",

month = aug,

doi = "10.1177/1741826711416046",

language = "English",

volume = "19",

pages = "746--54",

journal = "European Journal of Preventive Cardiology",

issn = "2047-4873",

publisher = "SAGE Publications",

number = "4",

}

TY - JOUR

T1 - No gender differences in prognosis and preventive treatment in patients with AMI without significant stenoses

AU - Hansen, Kim

AU - Hvelplund, Anders

AU - Abildstrøm, Steen Zabell

AU - Prescott, Eva

AU - Madsen, Mette

AU - Madsen, Jan Kyst

AU - Jensen, Jan Skov

AU - Thuesen, Leif

AU - Thayssen, Per

AU - Tilsted, Hans Henrik

AU - Jørgensen, Erik

AU - Galatius, Søren

PY - 2012/8

Y1 - 2012/8

N2 - Objective: To investigate possible gender differences in patients with acute myocardial infarction (AMI) and without significant stenoses on coronary angiography (CAG) regarding prognosis and use of secondary preventive medication. Design: Nationwide register-based cohort study. Patients: By compiling data from Danish registries, we identified 20,800 patients hospitalized with AMI during 2005-2007. We included the 834 women and 761 men without significant stenoses on CAG who were discharged and alive after 60 days. Main outcome measures: All-cause mortality, recurrent AMI, and redeeming a prescription for a lipid-lowering drug, beta-blocker, clopidogrel, or aspirin within 60 days of discharge. Results: During follow-up, 97 women and 60 men died, resulting in a crude female/male hazard ratio (HR) of 1.51 (95% CI 1.09-2.08). After adjustment for age, time-period, and comorbidity, the gender difference was attenuated (HR 1.22, 95% CI 0.86-1.72). AMI recurrence was experienced by 28 women and 29 men with a female/male HR 0.88 (95% CI 0.52-1.48). After multivariable adjustment results were similar (HR 0.84, 95% CI 0.50-1.43). More women than men redeemed a prescription for lipid-lowering drugs with no differences in other medication. In the adjusted models lipid-lowering drugs, beta-blockers, clopidogrel, and aspirin were all redeemed equally with odds ratio (OR) 1.25 (95% CI 0.99-1.59), OR 1.10 (95% CI 0.88-1.37), OR 1.09 (95% CI 0.88-1.34), and OR 1.13 (95% CI 0.90-1.42), respectively. Conclusion: Our study shows that in a population of patients with a first admission for AMI and no significant stenoses on CAG, women share the same prospects as men regarding long-term prognosis and the extent of secondary preventive medical treatment.

AB - Objective: To investigate possible gender differences in patients with acute myocardial infarction (AMI) and without significant stenoses on coronary angiography (CAG) regarding prognosis and use of secondary preventive medication. Design: Nationwide register-based cohort study. Patients: By compiling data from Danish registries, we identified 20,800 patients hospitalized with AMI during 2005-2007. We included the 834 women and 761 men without significant stenoses on CAG who were discharged and alive after 60 days. Main outcome measures: All-cause mortality, recurrent AMI, and redeeming a prescription for a lipid-lowering drug, beta-blocker, clopidogrel, or aspirin within 60 days of discharge. Results: During follow-up, 97 women and 60 men died, resulting in a crude female/male hazard ratio (HR) of 1.51 (95% CI 1.09-2.08). After adjustment for age, time-period, and comorbidity, the gender difference was attenuated (HR 1.22, 95% CI 0.86-1.72). AMI recurrence was experienced by 28 women and 29 men with a female/male HR 0.88 (95% CI 0.52-1.48). After multivariable adjustment results were similar (HR 0.84, 95% CI 0.50-1.43). More women than men redeemed a prescription for lipid-lowering drugs with no differences in other medication. In the adjusted models lipid-lowering drugs, beta-blockers, clopidogrel, and aspirin were all redeemed equally with odds ratio (OR) 1.25 (95% CI 0.99-1.59), OR 1.10 (95% CI 0.88-1.37), OR 1.09 (95% CI 0.88-1.34), and OR 1.13 (95% CI 0.90-1.42), respectively. Conclusion: Our study shows that in a population of patients with a first admission for AMI and no significant stenoses on CAG, women share the same prospects as men regarding long-term prognosis and the extent of secondary preventive medical treatment.

U2 - 10.1177/1741826711416046

DO - 10.1177/1741826711416046

M3 - Journal article

C2 - 21724682

SN - 2047-4873

VL - 19

SP - 746

EP - 754

JO - European Journal of Preventive Cardiology

JF - European Journal of Preventive Cardiology

IS - 4

ER -

No gender differences in prognosis and preventive treatment in patients with AMI without significant stenoses

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