No evidence of increased breast cancer risk for proven noncarriers from BRCA1 and BRCA2 families

TY - JOUR

T1 - No evidence of increased breast cancer risk for proven noncarriers from BRCA1 and BRCA2 families

AU - Roed Nielsen, Henriette

AU - Petersen, Janne

AU - Krogh, Lotte Nylandsted

AU - Nilbert, Mef

AU - Skytte, Anne-Bine

PY - 2016/10/1

Y1 - 2016/10/1

N2 - In families screened for mutations in the BRCA1 or BRCA2 genes and found to have a segregating mutation the breast cancer risk for women shown not to carry the family-specific mutation might be at above "average" risk. We assessed the risk of breast cancer in a clinic based cohort of 725 female proven noncarriers in 239 BRCA1 and BRCA2 families compared with birth-matched controls from the Danish Civil Registration System. Prospective analysis showed no significantly increased risk for breast cancer in noncarriers with a hazard ratio of 0.67 [95 % confidence interval (CI) 0.32-1.42, p = 0.29] for all family members who tested negative and 0.87 (95 % CI 0.38-1.97, p = 0.73) for non-carries who were first-degree relatives of mutation carriers. Proven noncarriers from BRCA1 and BRCA2 families have no markedly increased risk for breast cancer compared to the general population, and our data do not suggest targeted breast cancer surveillance for noncarriers from BRCA1 and BRCA2 families.

AB - In families screened for mutations in the BRCA1 or BRCA2 genes and found to have a segregating mutation the breast cancer risk for women shown not to carry the family-specific mutation might be at above "average" risk. We assessed the risk of breast cancer in a clinic based cohort of 725 female proven noncarriers in 239 BRCA1 and BRCA2 families compared with birth-matched controls from the Danish Civil Registration System. Prospective analysis showed no significantly increased risk for breast cancer in noncarriers with a hazard ratio of 0.67 [95 % confidence interval (CI) 0.32-1.42, p = 0.29] for all family members who tested negative and 0.87 (95 % CI 0.38-1.97, p = 0.73) for non-carries who were first-degree relatives of mutation carriers. Proven noncarriers from BRCA1 and BRCA2 families have no markedly increased risk for breast cancer compared to the general population, and our data do not suggest targeted breast cancer surveillance for noncarriers from BRCA1 and BRCA2 families.

KW - Journal Article

U2 - 10.1007/s10689-016-9898-0

DO - 10.1007/s10689-016-9898-0

M3 - Journal article

C2 - 26951453

SN - 1389-9600

VL - 15

SP - 523

EP - 528

JO - Familial Cancer

JF - Familial Cancer

IS - 4

ER -