No evidence for an anti-inflammatory effect of escitalopram intervention in healthy individuals with a family history of depression

Eva Haastrup; Ulla Knorr; Christian Erikstrup; Lars Vedel Kessing; Henrik Ullum

doi:10.1016/j.jneuroim.2011.12.006

No evidence for an anti-inflammatory effect of escitalopram intervention in healthy individuals with a family history of depression

Eva Haastrup, Ulla Knorr, Christian Erikstrup, Lars Vedel Kessing, Henrik Ullum

14 Citationer (Scopus)

Abstract

Inflammation may contribute to the pathogenesis of depression and antidepressants are hypothesised to have an anti-inflammatory effect. In this randomised double-blinded trial we investigated the cytokine levels in supernatants of stimulated whole blood samples from first degree relatives to patients with depression randomised to a single daily dose of either 10mg escitalopram or placebo for four weeks. No significant differences were found in any of the cytokine levels between the participants treated with escitalopram (n=21) or placebo (n=23). Our data does thus not support the hypothesis of a global anti-inflammatory effect of escitalopram on cytokines in healthy subjects.

Originalsprog	Engelsk
Tidsskrift	Journal of Neuroimmunology
ISSN	0165-5728
DOI	https://doi.org/10.1016/j.jneuroim.2011.12.006
Status	Udgivet - 29 feb. 2012

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10.1016/j.jneuroim.2011.12.006

Citationsformater

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title = "No evidence for an anti-inflammatory effect of escitalopram intervention in healthy individuals with a family history of depression",

abstract = "Inflammation may contribute to the pathogenesis of depression and antidepressants are hypothesised to have an anti-inflammatory effect. In this randomised double-blinded trial we investigated the cytokine levels in supernatants of stimulated whole blood samples from first degree relatives to patients with depression randomised to a single daily dose of either 10mg escitalopram or placebo for four weeks. No significant differences were found in any of the cytokine levels between the participants treated with escitalopram (n=21) or placebo (n=23). Our data does thus not support the hypothesis of a global anti-inflammatory effect of escitalopram on cytokines in healthy subjects.",

author = "Eva Haastrup and Ulla Knorr and Christian Erikstrup and Kessing, {Lars Vedel} and Henrik Ullum",

note = "Copyright {\textcopyright} 2011. Published by Elsevier B.V.",

year = "2012",

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TY - JOUR

T1 - No evidence for an anti-inflammatory effect of escitalopram intervention in healthy individuals with a family history of depression

AU - Haastrup, Eva

AU - Knorr, Ulla

AU - Erikstrup, Christian

AU - Kessing, Lars Vedel

AU - Ullum, Henrik

PY - 2012/2/29

Y1 - 2012/2/29

N2 - Inflammation may contribute to the pathogenesis of depression and antidepressants are hypothesised to have an anti-inflammatory effect. In this randomised double-blinded trial we investigated the cytokine levels in supernatants of stimulated whole blood samples from first degree relatives to patients with depression randomised to a single daily dose of either 10mg escitalopram or placebo for four weeks. No significant differences were found in any of the cytokine levels between the participants treated with escitalopram (n=21) or placebo (n=23). Our data does thus not support the hypothesis of a global anti-inflammatory effect of escitalopram on cytokines in healthy subjects.

AB - Inflammation may contribute to the pathogenesis of depression and antidepressants are hypothesised to have an anti-inflammatory effect. In this randomised double-blinded trial we investigated the cytokine levels in supernatants of stimulated whole blood samples from first degree relatives to patients with depression randomised to a single daily dose of either 10mg escitalopram or placebo for four weeks. No significant differences were found in any of the cytokine levels between the participants treated with escitalopram (n=21) or placebo (n=23). Our data does thus not support the hypothesis of a global anti-inflammatory effect of escitalopram on cytokines in healthy subjects.

U2 - 10.1016/j.jneuroim.2011.12.006

DO - 10.1016/j.jneuroim.2011.12.006

M3 - Journal article

C2 - 22244574

SN - 0165-5728

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

No evidence for an anti-inflammatory effect of escitalopram intervention in healthy individuals with a family history of depression

Abstract

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