@article{38f343dd25b74ea88afe89b7d6126419,
title = "Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt",
abstract = "Pro-inflammatory cytokines cause beta cell secretory dysfunction and apoptosis--a process implicated in the pathogenesis of type 1 diabetes. Cytokines induce the expression of inducible nitric oxide (NO) synthase (iNOS) leading to NO production. NO contributes to cytokine-induced apoptosis, but the underlying mechanisms are unclear. The aim of this study was to investigate whether NO modulates signalling via mitogen-activated protein kinases (MAPKs) and Akt.",
keywords = "Animals, Apoptosis, Blotting, Western, Cell Separation, Cells, Cultured, Cytokines, Dose-Response Relationship, Drug, Enzyme Activation, Enzyme Inhibitors, Humans, Insulin, Insulin-Secreting Cells, MAP Kinase Kinase 4, Mice, Mitogen-Activated Protein Kinases, NG-Nitroarginine Methyl Ester, Nitric Oxide, Nitric Oxide Donors, Nitric Oxide Synthase Type II, Oncogene Protein v-akt, S-Nitroso-N-Acetylpenicillamine, Signal Transduction, p38 Mitogen-Activated Protein Kinases",
author = "J St{\o}rling and J Binzer and Annica Andersson and Z{\"u}llig, {R A} and M Tonnesen and Knudsen, {Ren{\'e} Lehmann Pulz} and Spinas, {G A} and S Sandler and N Billestrup and Thomas Mandrup-Poulsen",
year = "2005",
month = oct,
day = "1",
doi = "10.1007/s00125-005-1912-2",
language = "English",
volume = "48",
pages = "2039--50",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",
number = "10",
}
