Newborn regional body composition is influenced by maternal obesity, gestational weight gain and the birthweight standard score

TY - JOUR

T1 - Newborn regional body composition is influenced by maternal obesity, gestational weight gain and the birthweight standard score

AU - Carlsen, E M

AU - Renault, Kristina Martha

AU - Nørgaard, K

AU - Nilas, Lisbeth

AU - Jensen, J E B

AU - Hyldstrup, L

AU - Michaelsen, Kim F.

AU - Cortes, Dina

AU - Pryds, Ole

N1 - CURIS 2014 NEXS 266

PY - 2014/9

Y1 - 2014/9

N2 - Aim This study investigated whether newborn body composition is influenced by prepregnancy obesity and gestational weight gain (GWG) and explored any associations between body composition and birthweight standard score (z-score), categorised by size for gestational age. Methods We recruited 231 obese and 80 normal weight mothers and their newborn infants and assessed the babies' body composition using dual-energy X-ray absorptiometry. Results The total and abdominal fat masses of infants born to mother who were obese before pregnancy were 135 g (p < 0.001) and 18 g (p < 0.001) higher than the offspring of normal weight mothers. The infants' fat mass increased by 11 g (p < 0.001) for every kilogram of GWG. There were no associations between prepregnancy obesity and fat-free mass. The fat percentage was significantly higher in infants who were large for gestational age (15.3%) than small for gestational age (5.2%) and appropriate for gestational age (9.8%) (p < 0.001). Lower birthweight z-score was associated with a higher proportion of abdominal fat mass (p = 0.009). Conclusion Infants born to obese mothers had higher fat mass at birth, with abdominal fat accumulation. Low birthweight was associated with a lower crude abdominal fat mass, but a higher proportion of total fat mass placed abdominally.

AB - Aim This study investigated whether newborn body composition is influenced by prepregnancy obesity and gestational weight gain (GWG) and explored any associations between body composition and birthweight standard score (z-score), categorised by size for gestational age. Methods We recruited 231 obese and 80 normal weight mothers and their newborn infants and assessed the babies' body composition using dual-energy X-ray absorptiometry. Results The total and abdominal fat masses of infants born to mother who were obese before pregnancy were 135 g (p < 0.001) and 18 g (p < 0.001) higher than the offspring of normal weight mothers. The infants' fat mass increased by 11 g (p < 0.001) for every kilogram of GWG. There were no associations between prepregnancy obesity and fat-free mass. The fat percentage was significantly higher in infants who were large for gestational age (15.3%) than small for gestational age (5.2%) and appropriate for gestational age (9.8%) (p < 0.001). Lower birthweight z-score was associated with a higher proportion of abdominal fat mass (p = 0.009). Conclusion Infants born to obese mothers had higher fat mass at birth, with abdominal fat accumulation. Low birthweight was associated with a lower crude abdominal fat mass, but a higher proportion of total fat mass placed abdominally.

U2 - 10.1111/apa.12713

DO - 10.1111/apa.12713

M3 - Journal article

C2 - 24942370

SN - 0803-5253

VL - 103

SP - 939

EP - 945

JO - Acta Paediatrica

JF - Acta Paediatrica

IS - 9

ER -