TY - JOUR
T1 - New descriptors of T-wave morphology are independent of heart rate
AU - Andersen, Mads Peter
AU - Xue, Joel Q
AU - Graff, Claus
AU - Kanters, Jørgen K.
AU - Toft, Egon
AU - Struijk, Johannes J.
PY - 2008
Y1 - 2008
N2 - T-wave morphology descriptors are sensitive to drug-induced changes and may be a useful addition to the QT interval in cardiac safety trials. Intrasubject heart rate dependence of T-wave morphology was investigated in a sample of 39 healthy individuals. Ten-second electrocardiograms were obtained from daytime Holter recordings. Duration parameters (QT, ToTe, TpTe, and others), a number of basic T-wave morphology parameters (amplitude, area, and others) as well as advanced morphology descriptors (asymmetry, flatness, and others) were measured automatically. Heart rate dependence was examined by means of analysis of covariance. The results showed clear heart rate dependence for the QT interval (R(2) = 0.53-0.57) and a moderate degree of heart rate dependence for the basic morphology parameters (amplitude, area, and others) (R(2) = 0.17-0.42). Both the advanced T-wave descriptors (asymmetry, flatness, and others), ToTe intervals and TpTe intervals, were practically independent of heart rate (R(2) = 0-0.08), making heart rate correction unnecessary for these parameters.
AB - T-wave morphology descriptors are sensitive to drug-induced changes and may be a useful addition to the QT interval in cardiac safety trials. Intrasubject heart rate dependence of T-wave morphology was investigated in a sample of 39 healthy individuals. Ten-second electrocardiograms were obtained from daytime Holter recordings. Duration parameters (QT, ToTe, TpTe, and others), a number of basic T-wave morphology parameters (amplitude, area, and others) as well as advanced morphology descriptors (asymmetry, flatness, and others) were measured automatically. Heart rate dependence was examined by means of analysis of covariance. The results showed clear heart rate dependence for the QT interval (R(2) = 0.53-0.57) and a moderate degree of heart rate dependence for the basic morphology parameters (amplitude, area, and others) (R(2) = 0.17-0.42). Both the advanced T-wave descriptors (asymmetry, flatness, and others), ToTe intervals and TpTe intervals, were practically independent of heart rate (R(2) = 0-0.08), making heart rate correction unnecessary for these parameters.
KW - Algorithms
KW - Artifacts
KW - Diagnosis, Computer-Assisted
KW - Electrocardiography
KW - Heart Rate
KW - Humans
KW - Pattern Recognition, Automated
KW - Reproducibility of Results
KW - Sensitivity and Specificity
U2 - 10.1016/j.jelectrocard.2008.07.021
DO - 10.1016/j.jelectrocard.2008.07.021
M3 - Journal article
C2 - 18804787
SN - 0022-0736
VL - 41
SP - 557
EP - 561
JO - Journal of Electrocardiology
JF - Journal of Electrocardiology
IS - 6
ER -