Neutralizing antibodies to hepatitis C virus in perinatally infected children followed up prospectively

Jean-Christophe Meunier; Jens Bukh; Giacomo Diaz; Pier-Angelo Tovo; Anna Maria Casadei; Isabella Quinti; Raffaele Iorio; Suzanne Emerson; Robert H Purcell; Patrizia Farci

doi:10.1093/infdis/jir631

Neutralizing antibodies to hepatitis C virus in perinatally infected children followed up prospectively

Jean-Christophe Meunier, Jens Bukh, Giacomo Diaz, Pier-Angelo Tovo, Anna Maria Casadei, Isabella Quinti, Raffaele Iorio, Suzanne Emerson, Robert H Purcell, Patrizia Farci

LUKKET: Institut for Immunologi og Mikrobiologi

8 Citationer (Scopus)

Abstract

Little is known about the presence and role of neutralizing antibodies (NtAbs) in perinatal hepatitis C virus (HCV) infection. Using HCV pseudoparticles, NtAbs were studied longitudinally in 12 HCV-infected children with or without evidence of acute hepatitis during the first year of life. Broadly reactive NtAbs of maternal origin did not prevent vertical HCV transmission or progression to chronicity. NtAbs against homologous genotype or subtype appeared during the chronic phase and were more abundant and sustained in children with acute hepatitis. Cross-reactive NtAbs were present in both groups of children, but their appearance did not correlate with better control of viremia or HCV clearance.

Originalsprog	Engelsk
Tidsskrift	Journal of Infectious Diseases
Vol/bind	204
Udgave nummer	11
Sider (fra-til)	1741-5
Antal sider	5
ISSN	0022-1899
DOI	https://doi.org/10.1093/infdis/jir631
Status	Udgivet - 1 dec. 2011

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10.1093/infdis/jir631

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@article{29800b01a16944e6aae7e81b883b7932,

title = "Neutralizing antibodies to hepatitis C virus in perinatally infected children followed up prospectively",

abstract = "Little is known about the presence and role of neutralizing antibodies (NtAbs) in perinatal hepatitis C virus (HCV) infection. Using HCV pseudoparticles, NtAbs were studied longitudinally in 12 HCV-infected children with or without evidence of acute hepatitis during the first year of life. Broadly reactive NtAbs of maternal origin did not prevent vertical HCV transmission or progression to chronicity. NtAbs against homologous genotype or subtype appeared during the chronic phase and were more abundant and sustained in children with acute hepatitis. Cross-reactive NtAbs were present in both groups of children, but their appearance did not correlate with better control of viremia or HCV clearance.",

keywords = "Adolescent, Alanine Transaminase, Antibodies, Neutralizing, Child, Child, Preschool, Female, Genotype, Hepacivirus, Hepatitis C, Hepatitis C Antibodies, Humans, Infant, Infectious Disease Transmission, Vertical, Longitudinal Studies, Male, Prospective Studies, RNA, Viral, Statistics, Nonparametric, Viremia",

author = "Jean-Christophe Meunier and Jens Bukh and Giacomo Diaz and Pier-Angelo Tovo and Casadei, {Anna Maria} and Isabella Quinti and Raffaele Iorio and Suzanne Emerson and Purcell, {Robert H} and Patrizia Farci",

year = "2011",

month = dec,

day = "1",

doi = "10.1093/infdis/jir631",

language = "English",

volume = "204",

pages = "1741--5",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "11",

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TY - JOUR

T1 - Neutralizing antibodies to hepatitis C virus in perinatally infected children followed up prospectively

AU - Meunier, Jean-Christophe

AU - Bukh, Jens

AU - Diaz, Giacomo

AU - Tovo, Pier-Angelo

AU - Casadei, Anna Maria

AU - Quinti, Isabella

AU - Iorio, Raffaele

AU - Emerson, Suzanne

AU - Purcell, Robert H

AU - Farci, Patrizia

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Little is known about the presence and role of neutralizing antibodies (NtAbs) in perinatal hepatitis C virus (HCV) infection. Using HCV pseudoparticles, NtAbs were studied longitudinally in 12 HCV-infected children with or without evidence of acute hepatitis during the first year of life. Broadly reactive NtAbs of maternal origin did not prevent vertical HCV transmission or progression to chronicity. NtAbs against homologous genotype or subtype appeared during the chronic phase and were more abundant and sustained in children with acute hepatitis. Cross-reactive NtAbs were present in both groups of children, but their appearance did not correlate with better control of viremia or HCV clearance.

AB - Little is known about the presence and role of neutralizing antibodies (NtAbs) in perinatal hepatitis C virus (HCV) infection. Using HCV pseudoparticles, NtAbs were studied longitudinally in 12 HCV-infected children with or without evidence of acute hepatitis during the first year of life. Broadly reactive NtAbs of maternal origin did not prevent vertical HCV transmission or progression to chronicity. NtAbs against homologous genotype or subtype appeared during the chronic phase and were more abundant and sustained in children with acute hepatitis. Cross-reactive NtAbs were present in both groups of children, but their appearance did not correlate with better control of viremia or HCV clearance.

KW - Adolescent

KW - Alanine Transaminase

KW - Antibodies, Neutralizing

KW - Child

KW - Child, Preschool

KW - Female

KW - Genotype

KW - Hepacivirus

KW - Hepatitis C

KW - Hepatitis C Antibodies

KW - Humans

KW - Infant

KW - Infectious Disease Transmission, Vertical

KW - Longitudinal Studies

KW - Male

KW - Prospective Studies

KW - RNA, Viral

KW - Statistics, Nonparametric

KW - Viremia

U2 - 10.1093/infdis/jir631

DO - 10.1093/infdis/jir631

M3 - Journal article

C2 - 22006993

SN - 0022-1899

VL - 204

SP - 1741

EP - 1745

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 11

ER -

Neutralizing antibodies to hepatitis C virus in perinatally infected children followed up prospectively

Abstract

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