Neutralizing antibodies hamper IFNbeta bioactivity and treatment effect on MRI in patients with MS

TY - JOUR

T1 - Neutralizing antibodies hamper IFNbeta bioactivity and treatment effect on MRI in patients with MS

AU - Sorensen, P Soelberg

AU - Petersen, Thomas Tscherning

AU - Kahr Mathiesen, Henrik

AU - Langkilde, A R

AU - Ross, C

AU - Ravnborg, Mads

AU - Bendtzen, K

AU - Solberg Sorensen, P

AU - Tscherning, MD

AU - Langkilde, AR

AU - Ross, C

AU - Bendtzen, K

PY - 2006

Y1 - 2006

N2 - We measured neutralizing antibodies (NABs) and the in vivo biologic response to interferon-beta on neopterin and beta(2)-microglobulin blood levels. All NAB-negative patients had an in vivo biologic response (full or partial), whereas all high-level positive patients had no response. High-level NAB patients had more MRI activity than NAB-negative patients (p = 0.031). Patients with a full response had less MRI activity than patients without biologic response (p = 0.032).

AB - We measured neutralizing antibodies (NABs) and the in vivo biologic response to interferon-beta on neopterin and beta(2)-microglobulin blood levels. All NAB-negative patients had an in vivo biologic response (full or partial), whereas all high-level positive patients had no response. High-level NAB patients had more MRI activity than NAB-negative patients (p = 0.031). Patients with a full response had less MRI activity than patients without biologic response (p = 0.032).

U2 - 10.1212/01.wnl.0000242884.76598.bb

DO - 10.1212/01.wnl.0000242884.76598.bb

M3 - Journal article

C2 - 17101906

SN - 0028-3878

VL - 67

SP - 1681

EP - 1683

JO - Neurology

JF - Neurology

IS - 9

ER -