Neuronal cell fate decisions:  O2 and CO2 sensing neurons require egl-13/Sox5

TY - JOUR

T1 - Neuronal cell fate decisions:  O2 and CO2 sensing neurons require egl-13/Sox5

AU - Gramstrup Petersen, Jakob

AU - Pocock, Roger David John

PY - 2013/10/1

Y1 - 2013/10/1

N2 - We recently conducted a study that aimed to describe the differentiation mechanisms used to generate O2 and CO2 sensing neurons in C. elegans. We identified egl-13/Sox5 to be required for the differentiation of both O2 and CO2 sensing neurons. We found that egl-13 functions cell autonomously to drive O2 and CO2 sensing neuron fate and is therefore essential for O2 and CO2 sensing-induced behaviors. Through systematic dissection of the egl-13 promoter we identified upstream regulators of egl-13 and proposed a model of how differentiation of O2 and CO2 sensing neurons is regulated. In this commentary we discuss our findings and open questions we wish to address in future studies.

AB - We recently conducted a study that aimed to describe the differentiation mechanisms used to generate O2 and CO2 sensing neurons in C. elegans. We identified egl-13/Sox5 to be required for the differentiation of both O2 and CO2 sensing neurons. We found that egl-13 functions cell autonomously to drive O2 and CO2 sensing neuron fate and is therefore essential for O2 and CO2 sensing-induced behaviors. Through systematic dissection of the egl-13 promoter we identified upstream regulators of egl-13 and proposed a model of how differentiation of O2 and CO2 sensing neurons is regulated. In this commentary we discuss our findings and open questions we wish to address in future studies.

U2 - 10.4161/worm.27284

DO - 10.4161/worm.27284

M3 - Journal article

C2 - 24744985

SN - 2162-4046

VL - 2

SP - e27284

JO - Worm

JF - Worm

IS - 4

ER -