TY - JOUR
T1 - Neonatal anthropometrics and correlation to childhood obesity--data from the Danish Children's Obesity Clinic
AU - Lausten-Thomsen, Ulrik
AU - Bille, Dorthe Sadowa
AU - Nässlund, Ida
AU - Folskov, Lise
AU - Larsen, Torben
AU - Holm, Jens-Christian
PY - 2013/6
Y1 - 2013/6
N2 - Recent evidence has demonstrated the prenatal initiation of childhood obesity as epidemiological studies and animal studies have illustrated the effect of the intrauterine milieu for subsequent development of childhood obesity. This study investigates the relationship between severe childhood obesity and the preceding in utero conditions expressed by birth weight and birth length, birth-weight-for-gestational-age and neonatal ponderal index in a Danish cohort of 1,171 severely obese children (median age 11.48 years, range 3.13 to 17.98 years) with a mean body mass index-standard derivation score (BMI-SDS) of +2.96 (range +1.65 to +9.72) treated in our national referral centre. In a linear general regression model adjusted for socioeconomic status and breastfeeding duration, a significant linear correlation between BMI-SDS at time of enrolment and both birth weight (p, 3.8 × 10-6) and birth length (p, 6.1 × 10-4), birth-weight-for-gestational-age (p, 4.3 × 10-7) and the neonatal ponderal index (p, 0.02) was demonstrated. Duration of breastfeeding, however, was not found to be significant for either the BMI-SDS/BW or the BMI-SDS/BL correlation. Conclusion: These results indicate that the prenatal period can be considered as a potential window of opportunity for prevention of childhood overweight and obesity and anthropological measurements may in theory be used to help identify neonates at high risk for developing childhood obesity.
AB - Recent evidence has demonstrated the prenatal initiation of childhood obesity as epidemiological studies and animal studies have illustrated the effect of the intrauterine milieu for subsequent development of childhood obesity. This study investigates the relationship between severe childhood obesity and the preceding in utero conditions expressed by birth weight and birth length, birth-weight-for-gestational-age and neonatal ponderal index in a Danish cohort of 1,171 severely obese children (median age 11.48 years, range 3.13 to 17.98 years) with a mean body mass index-standard derivation score (BMI-SDS) of +2.96 (range +1.65 to +9.72) treated in our national referral centre. In a linear general regression model adjusted for socioeconomic status and breastfeeding duration, a significant linear correlation between BMI-SDS at time of enrolment and both birth weight (p, 3.8 × 10-6) and birth length (p, 6.1 × 10-4), birth-weight-for-gestational-age (p, 4.3 × 10-7) and the neonatal ponderal index (p, 0.02) was demonstrated. Duration of breastfeeding, however, was not found to be significant for either the BMI-SDS/BW or the BMI-SDS/BL correlation. Conclusion: These results indicate that the prenatal period can be considered as a potential window of opportunity for prevention of childhood overweight and obesity and anthropological measurements may in theory be used to help identify neonates at high risk for developing childhood obesity.
KW - Adolescent
KW - Birth Weight
KW - Body Height
KW - Child
KW - Child, Preschool
KW - Denmark
KW - Female
KW - Gestational Age
KW - Humans
KW - Infant, Newborn
KW - Linear Models
KW - Male
KW - Pediatric Obesity
KW - Pregnancy
KW - Prenatal Exposure Delayed Effects
KW - Retrospective Studies
KW - Severity of Illness Index
U2 - 10.1007/s00431-013-1949-z
DO - 10.1007/s00431-013-1949-z
M3 - Journal article
C2 - 23371390
SN - 0340-6199
VL - 172
SP - 747
EP - 751
JO - Acta Paediatrica Hungarica
JF - Acta Paediatrica Hungarica
IS - 6
ER -
