TY - JOUR
T1 - Neocortical glial cell numbers in human brains
AU - Pelvig, D.P.
AU - Pakkenberg, H.
AU - Stark, A.K.
AU - Pakkenberg, B.
N1 - Times Cited: 0ArticleEnglishPakkenberg, BHS Bispebjerg Univ Hosp, Res Lab Stereol & Neurosci, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, DenmarkCited References Count: 38356JPELSEVIER SCIENCE INC360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USANEW YORK
PY - 2008
Y1 - 2008
N2 - Stereological cell counting was applied to post-mortem neocortices of human brains from 31 normal individuals, age 18-93 years, 18 females (average age 65 years, range 18-93) and 13 males (average age 57 years, range 19-87). The cells were differentiated in astrocytes, oligodendrocytes, microglia and neurons and counting were done in each of the four lobes. The study showed that the different subpopulations of glial cells behave differently as a function of age; the number of oligodendrocytes showed a significant 27% decrease over adult life and a strong correlation to the total number of neurons while the total astrocyte number is constant through life; finally males have a 28% higher number of neocortical glial cells and a 19% higher neocortical neuron number than females. The overall total number of neocortical neurons and glial cells was 49.3 billion in females and 65.2 billion in males, a difference of 24% with a high biological variance. These numbers can serve as reference values in quantitative studies of the human neocortex. (C) 2007 Elsevier Inc. All rights reserved
Udgivelsesdato: 2008/11
AB - Stereological cell counting was applied to post-mortem neocortices of human brains from 31 normal individuals, age 18-93 years, 18 females (average age 65 years, range 18-93) and 13 males (average age 57 years, range 19-87). The cells were differentiated in astrocytes, oligodendrocytes, microglia and neurons and counting were done in each of the four lobes. The study showed that the different subpopulations of glial cells behave differently as a function of age; the number of oligodendrocytes showed a significant 27% decrease over adult life and a strong correlation to the total number of neurons while the total astrocyte number is constant through life; finally males have a 28% higher number of neocortical glial cells and a 19% higher neocortical neuron number than females. The overall total number of neocortical neurons and glial cells was 49.3 billion in females and 65.2 billion in males, a difference of 24% with a high biological variance. These numbers can serve as reference values in quantitative studies of the human neocortex. (C) 2007 Elsevier Inc. All rights reserved
Udgivelsesdato: 2008/11
M3 - Journal article
SN - 0197-4580
VL - 29
SP - 1754
EP - 1762
JO - Neurobiology of Aging
JF - Neurobiology of Aging
IS - 11
ER -