TY - JOUR
T1 - Naturally death-resistant precursor cells revealed as the origin of retinoblastoma.
AU - Trinh, Emmanuelle
AU - Lazzerini Denchi, Eros
AU - Helin, Kristian
N1 - Keywords: Alleles; Animals; Apoptosis; Cell Death; Cell Differentiation; Cell Division; Humans; Mice; Mice, Transgenic; Models, Biological; Mutation; Neuroblastoma; Retinoblastoma Protein
PY - 2004
Y1 - 2004
N2 - The molecular mechanisms and the cell-of-origin leading to retinoblastoma are not well defined. In this issue of Cancer Cell, Bremner and colleagues describe the first inheritable model of retinoblastoma, revealing that loss of the pocket proteins pRb and p107 deregulates cell cycle exit in retinal precursors. The authors show that a subset of these precursors contain an inherent resistance to apoptosis, and that while most terminally differentiate, some are likely to acquire additional mutations, leading to tumor formation. Thus, this work defines the cell-of-origin of retinoblastoma and suggests that mutations giving increased proliferative capacity are required for retinoblastoma development.
AB - The molecular mechanisms and the cell-of-origin leading to retinoblastoma are not well defined. In this issue of Cancer Cell, Bremner and colleagues describe the first inheritable model of retinoblastoma, revealing that loss of the pocket proteins pRb and p107 deregulates cell cycle exit in retinal precursors. The authors show that a subset of these precursors contain an inherent resistance to apoptosis, and that while most terminally differentiate, some are likely to acquire additional mutations, leading to tumor formation. Thus, this work defines the cell-of-origin of retinoblastoma and suggests that mutations giving increased proliferative capacity are required for retinoblastoma development.
U2 - 10.1016/j.ccr.2004.05.026
DO - 10.1016/j.ccr.2004.05.026
M3 - Review
C2 - 15193252
SN - 1535-6108
VL - 5
SP - 513
EP - 515
JO - Cancer Cell
JF - Cancer Cell
IS - 6
ER -
