Natural products as tools for studies of ligand-gated ion channels

TY - JOUR

T1 - Natural products as tools for studies of ligand-gated ion channels

AU - Strømgaard, Kristian

N1 - (c) 2005 The Japan Chemical Journal Forum and Wiley Periodicals, Inc.

PY - 2005

Y1 - 2005

N2 - Ligand-gated ion channels, or ionotropic receptors, constitute a group of membrane-bound proteins that regulate the flux of ions across the cell membrane. In the brain, ligand-gated ion channels mediate fast neurotransmission. They are crucial for normal brain function and involved in many diseases in the brain. Historically, natural products have been used extensively in biomedical studies and ultimately as drugs or leads for drug design. In studies of ligand-gated ion channels, natural products have been essential for the understanding of their structure and function. In the following a short survey of natural products and their use in studies of ligand-gated ion channels is given.

AB - Ligand-gated ion channels, or ionotropic receptors, constitute a group of membrane-bound proteins that regulate the flux of ions across the cell membrane. In the brain, ligand-gated ion channels mediate fast neurotransmission. They are crucial for normal brain function and involved in many diseases in the brain. Historically, natural products have been used extensively in biomedical studies and ultimately as drugs or leads for drug design. In studies of ligand-gated ion channels, natural products have been essential for the understanding of their structure and function. In the following a short survey of natural products and their use in studies of ligand-gated ion channels is given.

KW - Animals

KW - Biological Agents

KW - Humans

KW - Ion Channel Gating

KW - Ion Channels

KW - Ligands

KW - Protein Conformation

U2 - 10.1002/tcr.20048

DO - 10.1002/tcr.20048

M3 - Journal article

C2 - 16041746

SN - 1527-8999

VL - 5

SP - 229

EP - 239

JO - Chemical Record

JF - Chemical Record

IS - 4

ER -