Natriuretic peptides and cerebral hemodynamics

TY - JOUR

T1 - Natriuretic peptides and cerebral hemodynamics

AU - Guo, Song

AU - Barringer, Filippa

AU - Zois, Nora Elisabeth

AU - Goetze, Jens P

AU - Ashina, Messoud

N1 - Copyright © 2014 Elsevier B.V. All rights reserved.

PY - 2014/6

Y1 - 2014/6

N2 - Natriuretic peptides have emerged as important diagnostic and prognostic tools for cardiovascular disease. Plasma measurement of the bioactive peptides as well as precursor-derived fragments is a sensitive tool in assessing heart failure. In heart failure, the peptides are used as treatment in decompensated disease. In contrast, their biological effects on the cerebral hemodynamics are poorly understood. In this mini-review, we summarize the hemodynamic effects of the natriuretic peptides with a focus on the cerebral hemodynamics. In addition, we will discuss its potential implications in diseases where alteration of the cerebral hemodynamics plays a role such as migraine and acute brain injury including stroke. We conclude that a possible role of the peptides is feasible as evaluated from animal and in vitro studies, but more research is needed in humans to determine the precise response on cerebral vessels.

AB - Natriuretic peptides have emerged as important diagnostic and prognostic tools for cardiovascular disease. Plasma measurement of the bioactive peptides as well as precursor-derived fragments is a sensitive tool in assessing heart failure. In heart failure, the peptides are used as treatment in decompensated disease. In contrast, their biological effects on the cerebral hemodynamics are poorly understood. In this mini-review, we summarize the hemodynamic effects of the natriuretic peptides with a focus on the cerebral hemodynamics. In addition, we will discuss its potential implications in diseases where alteration of the cerebral hemodynamics plays a role such as migraine and acute brain injury including stroke. We conclude that a possible role of the peptides is feasible as evaluated from animal and in vitro studies, but more research is needed in humans to determine the precise response on cerebral vessels.

U2 - 10.1016/j.regpep.2014.07.003

DO - 10.1016/j.regpep.2014.07.003

M3 - Review

C2 - 25107278

SN - 0167-0115

VL - 192-193

SP - 15

EP - 23

JO - Regulatory Peptides

JF - Regulatory Peptides

ER -