National surveillance of fungemia in Denmark (2004 to 2009)

Maiken Cavling Arendrup; Brita Bruun; Jens Jørgen Christensen; Kurt Fuursted; Helle Krogh Johansen; Poul Kjaeldgaard; Jenny Dahl Knudsen; Lise Kristensen; Jens Møller; Lene Nielsen; Flemming Schønning Rosenvinge; Bent Røder; Henrik Carl Schønheyder; Marianne Thomsen; Kjeld Truberg

doi:10.1128/JCM.01811-10

National surveillance of fungemia in Denmark (2004 to 2009)

Maiken Cavling Arendrup, Brita Bruun, Jens Jørgen Christensen, Kurt Fuursted, Helle Krogh Johansen, Poul Kjaeldgaard, Jenny Dahl Knudsen, Lise Kristensen, Jens Møller, Lene Nielsen, Flemming Schønning Rosenvinge, Bent Røder, Henrik Carl Schønheyder, Marianne Thomsen, Kjeld Truberg

LUKKET: Institut for Immunologi og Mikrobiologi

184 Citationer (Scopus)

Abstract

A 6-year nationwide study of fungemia in Denmark was performed using data from an active fungemia surveillance program and from laboratory information systems in nonparticipating regions. A total of 2,820 episodes of fungemia were recorded. The incidence increased from 2004 to 2007 (7.7 to 9.6/100,000) and decreased slightly from 2008 to 2009 (8.7 to 8.6/100,000). The highest incidences were seen at the extremes of age (i.e., 11.3 and 37.1/100,000 for those 50 years of age. The species distribution varied significantly by both age and gender. Candida species accounted for 98% of the pathogens, and C. albicans was predominant, although the proportion decreased (64.4% to 53.2%, P <0.0001). C. glabrata ranked second, and the proportion increased (16.5% to 25.9%, P = 0.003). C. glabrata was more common in adults and females than in children and males, whereas C. tropicalis was more common in males (P = 0.020). C. krusei was a rare isolate (4.1%) except at one university hospital. Acquired resistance to amphotericin and echinocandins was rare. However, resistance to fluconazole (MIC of >4 µg/ml) occurred in C. albicans (7/1,183 [0.6%]), C. dubliniensis (2/65 [3.1%]), C. parapsilosis (5/83 [6.0%]), and C. tropicalis (7/104 [6.7%]). Overall, 70.8% of fungemia isolates were fully fluconazole susceptible, but the proportion decreased (79.7% to 68.9%, P = 0.02). The study confirmed an incidence rate of fungemia in Denmark three times higher than those in other Nordic countries and identified marked differences related to age and gender. Decreased susceptibility to fluconazole was frequent and increasing.

Originalsprog	Engelsk
Tidsskrift	Journal of Clinical Microbiology
Vol/bind	49
Udgave nummer	1
Sider (fra-til)	325-34
Antal sider	10
ISSN	0095-1137
DOI	https://doi.org/10.1128/JCM.01811-10 https://doi.org/10.1128/JCM.01811-10
Status	Udgivet - 1 jan. 2011

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Arendrup, M. C., Bruun, B., Christensen, J. J., Fuursted, K., Johansen, H. K., Kjaeldgaard, P., Knudsen, J. D., Kristensen, L., Møller, J., Nielsen, L., Rosenvinge, F. S., Røder, B., Schønheyder, H. C., Thomsen, M., & Truberg, K. (2011). National surveillance of fungemia in Denmark (2004 to 2009). Journal of Clinical Microbiology, 49(1), 325-34. https://doi.org/10.1128/JCM.01811-10, https://doi.org/10.1128/JCM.01811-10

Arendrup, MC, Bruun, B, Christensen, JJ, Fuursted, K, Johansen, HK, Kjaeldgaard, P, Knudsen, JD, Kristensen, L, Møller, J, Nielsen, L, Rosenvinge, FS, Røder, B, Schønheyder, HC, Thomsen, M & Truberg, K 2011, 'National surveillance of fungemia in Denmark (2004 to 2009)', Journal of Clinical Microbiology, bind 49, nr. 1, s. 325-34. https://doi.org/10.1128/JCM.01811-10, https://doi.org/10.1128/JCM.01811-10

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abstract = "A 6-year nationwide study of fungemia in Denmark was performed using data from an active fungemia surveillance program and from laboratory information systems in nonparticipating regions. A total of 2,820 episodes of fungemia were recorded. The incidence increased from 2004 to 2007 (7.7 to 9.6/100,000) and decreased slightly from 2008 to 2009 (8.7 to 8.6/100,000). The highest incidences were seen at the extremes of age (i.e., 11.3 and 37.1/100,000 for those 50 years of age. The species distribution varied significantly by both age and gender. Candida species accounted for 98% of the pathogens, and C. albicans was predominant, although the proportion decreased (64.4% to 53.2%, P <0.0001). C. glabrata ranked second, and the proportion increased (16.5% to 25.9%, P = 0.003). C. glabrata was more common in adults and females than in children and males, whereas C. tropicalis was more common in males (P = 0.020). C. krusei was a rare isolate (4.1%) except at one university hospital. Acquired resistance to amphotericin and echinocandins was rare. However, resistance to fluconazole (MIC of >4 µg/ml) occurred in C. albicans (7/1,183 [0.6%]), C. dubliniensis (2/65 [3.1%]), C. parapsilosis (5/83 [6.0%]), and C. tropicalis (7/104 [6.7%]). Overall, 70.8% of fungemia isolates were fully fluconazole susceptible, but the proportion decreased (79.7% to 68.9%, P = 0.02). The study confirmed an incidence rate of fungemia in Denmark three times higher than those in other Nordic countries and identified marked differences related to age and gender. Decreased susceptibility to fluconazole was frequent and increasing.",

author = "Arendrup, {Maiken Cavling} and Brita Bruun and Christensen, {Jens J{\o}rgen} and Kurt Fuursted and Johansen, {Helle Krogh} and Poul Kjaeldgaard and Knudsen, {Jenny Dahl} and Lise Kristensen and Jens M{\o}ller and Lene Nielsen and Rosenvinge, {Flemming Sch{\o}nning} and Bent R{\o}der and Sch{\o}nheyder, {Henrik Carl} and Marianne Thomsen and Kjeld Truberg",

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doi = "10.1128/JCM.01811-10",

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T1 - National surveillance of fungemia in Denmark (2004 to 2009)

AU - Arendrup, Maiken Cavling

AU - Bruun, Brita

AU - Christensen, Jens Jørgen

AU - Fuursted, Kurt

AU - Johansen, Helle Krogh

AU - Kjaeldgaard, Poul

AU - Knudsen, Jenny Dahl

AU - Kristensen, Lise

AU - Møller, Jens

AU - Nielsen, Lene

AU - Rosenvinge, Flemming Schønning

AU - Røder, Bent

AU - Schønheyder, Henrik Carl

AU - Thomsen, Marianne

AU - Truberg, Kjeld

PY - 2011/1/1

Y1 - 2011/1/1

N2 - A 6-year nationwide study of fungemia in Denmark was performed using data from an active fungemia surveillance program and from laboratory information systems in nonparticipating regions. A total of 2,820 episodes of fungemia were recorded. The incidence increased from 2004 to 2007 (7.7 to 9.6/100,000) and decreased slightly from 2008 to 2009 (8.7 to 8.6/100,000). The highest incidences were seen at the extremes of age (i.e., 11.3 and 37.1/100,000 for those 50 years of age. The species distribution varied significantly by both age and gender. Candida species accounted for 98% of the pathogens, and C. albicans was predominant, although the proportion decreased (64.4% to 53.2%, P <0.0001). C. glabrata ranked second, and the proportion increased (16.5% to 25.9%, P = 0.003). C. glabrata was more common in adults and females than in children and males, whereas C. tropicalis was more common in males (P = 0.020). C. krusei was a rare isolate (4.1%) except at one university hospital. Acquired resistance to amphotericin and echinocandins was rare. However, resistance to fluconazole (MIC of >4 µg/ml) occurred in C. albicans (7/1,183 [0.6%]), C. dubliniensis (2/65 [3.1%]), C. parapsilosis (5/83 [6.0%]), and C. tropicalis (7/104 [6.7%]). Overall, 70.8% of fungemia isolates were fully fluconazole susceptible, but the proportion decreased (79.7% to 68.9%, P = 0.02). The study confirmed an incidence rate of fungemia in Denmark three times higher than those in other Nordic countries and identified marked differences related to age and gender. Decreased susceptibility to fluconazole was frequent and increasing.

AB - A 6-year nationwide study of fungemia in Denmark was performed using data from an active fungemia surveillance program and from laboratory information systems in nonparticipating regions. A total of 2,820 episodes of fungemia were recorded. The incidence increased from 2004 to 2007 (7.7 to 9.6/100,000) and decreased slightly from 2008 to 2009 (8.7 to 8.6/100,000). The highest incidences were seen at the extremes of age (i.e., 11.3 and 37.1/100,000 for those 50 years of age. The species distribution varied significantly by both age and gender. Candida species accounted for 98% of the pathogens, and C. albicans was predominant, although the proportion decreased (64.4% to 53.2%, P <0.0001). C. glabrata ranked second, and the proportion increased (16.5% to 25.9%, P = 0.003). C. glabrata was more common in adults and females than in children and males, whereas C. tropicalis was more common in males (P = 0.020). C. krusei was a rare isolate (4.1%) except at one university hospital. Acquired resistance to amphotericin and echinocandins was rare. However, resistance to fluconazole (MIC of >4 µg/ml) occurred in C. albicans (7/1,183 [0.6%]), C. dubliniensis (2/65 [3.1%]), C. parapsilosis (5/83 [6.0%]), and C. tropicalis (7/104 [6.7%]). Overall, 70.8% of fungemia isolates were fully fluconazole susceptible, but the proportion decreased (79.7% to 68.9%, P = 0.02). The study confirmed an incidence rate of fungemia in Denmark three times higher than those in other Nordic countries and identified marked differences related to age and gender. Decreased susceptibility to fluconazole was frequent and increasing.

U2 - 10.1128/JCM.01811-10

DO - 10.1128/JCM.01811-10

M3 - Journal article

C2 - 20980569

SN - 0095-1137

VL - 49

SP - 325

EP - 334

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

IS - 1

ER -

National surveillance of fungemia in Denmark (2004 to 2009)

Abstract

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