Nanoparticle Surface Functionality Dictates Cellular and Systemic Toxicity

TY - JOUR

T1 - Nanoparticle Surface Functionality Dictates Cellular and Systemic Toxicity

AU - Saei, Amir Ata

AU - Yazdani, Mahdieh

AU - Lohse, Samuel E.

AU - Bakhtiary, Zahra

AU - Serpooshan, Vahid

AU - Ghavami, Mahdi

AU - Asadian, Mahtab

AU - Mashaghi, Samaneh

AU - Dreaden, Erik C.

AU - Mashaghi, Alireza

AU - Mahmoudi, Morteza

PY - 2017

Y1 - 2017

N2 - Engineered nanoparticles (NPs) have opened new frontiers in therapeutics and diagnostics in recent years. The surface functionality of these nanoparticles often predominates their interactions with various biological components of human body, and proper selection or control of surface functionality can greatly enhance subsequent therapeutic effects of NPs while diminishing their adverse side effects. In this review, we will focus on the effect of surface functionality on the cellular uptake and the transport of NPs by various subcellular processes.

AB - Engineered nanoparticles (NPs) have opened new frontiers in therapeutics and diagnostics in recent years. The surface functionality of these nanoparticles often predominates their interactions with various biological components of human body, and proper selection or control of surface functionality can greatly enhance subsequent therapeutic effects of NPs while diminishing their adverse side effects. In this review, we will focus on the effect of surface functionality on the cellular uptake and the transport of NPs by various subcellular processes.

U2 - 10.1021/acs.chemmater.7b01979

DO - 10.1021/acs.chemmater.7b01979

M3 - Review

AN - SCOPUS:85027887121

SN - 0897-4756

VL - 29

SP - 6578

EP - 6595

JO - Chemistry of Materials

JF - Chemistry of Materials

IS - 16

ER -