Myeloproliferative Neoplasms in Danish Twins

Michael Asger Andersen; Ole Weis Bjerrum; Ajenthen Ranjan; Vibe Skov; Torben A Kruse; Mads Thomassen; Axel Skytthe; Hans Carl Hasselbalch; Kaare Christensen

doi:10.1159/000488384

Myeloproliferative Neoplasms in Danish Twins

Michael Asger Andersen, Ole Weis Bjerrum, Ajenthen Ranjan, Vibe Skov, Torben A Kruse, Mads Thomassen, Axel Skytthe, Hans Carl Hasselbalch, Kaare Christensen

Institut for Klinisk Medicin

4 Citationer (Scopus)

Abstract

OBJECTIVE: Myeloproliferative neoplasms (MPNs) are a heterogeneous group of diseases characterized by clonal hyperproliferation of immature and mature cells of the myeloid lineage. Genetic differences have been proposed to play a role in the development of MPNs. Monozygotic twin pairs with MPNs have been reported in a few case reports, but the MPN concordance pattern in twins remains unknown.

METHOD: All twin pairs born in the period 1900-2010 were identified in the nationwide Danish Twin Registry. Only pairs with both twins alive on January 1, 1977, and those born thereafter were included to allow identification in the Danish National Patient Registry.

RESULTS: A total of 158 twin pairs were registered with an MPN diagnosis: 36 monozygotic, 104 dizygotic, and 18 pairs with unknown zygosity. MPNs were diagnosed in both twins in 4 pairs. The probandwise concordance rates for monozygotic twin pairs were higher than for dizygotic twin pairs (15 vs. 0%; p = 0.016).

CONCLUSION: An estimated concordance rate of 15% (95% CI 0.059-0.31) is modest, but given the rarity of MPNs this finding is clinically relevant and provides further support for the role of genetic predisposition in the development of MPNs.

Originalsprog	Engelsk
Tidsskrift	Acta Haematologica
Vol/bind	139
Udgave nummer	3
Sider (fra-til)	195-198
Antal sider	4
ISSN	0001-5792
DOI	https://doi.org/10.1159/000488384
Status	Udgivet - 1 maj 2018

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10.1159/000488384

Citationsformater

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title = "Myeloproliferative Neoplasms in Danish Twins",

abstract = "OBJECTIVE: Myeloproliferative neoplasms (MPNs) are a heterogeneous group of diseases characterized by clonal hyperproliferation of immature and mature cells of the myeloid lineage. Genetic differences have been proposed to play a role in the development of MPNs. Monozygotic twin pairs with MPNs have been reported in a few case reports, but the MPN concordance pattern in twins remains unknown.METHOD: All twin pairs born in the period 1900-2010 were identified in the nationwide Danish Twin Registry. Only pairs with both twins alive on January 1, 1977, and those born thereafter were included to allow identification in the Danish National Patient Registry.RESULTS: A total of 158 twin pairs were registered with an MPN diagnosis: 36 monozygotic, 104 dizygotic, and 18 pairs with unknown zygosity. MPNs were diagnosed in both twins in 4 pairs. The probandwise concordance rates for monozygotic twin pairs were higher than for dizygotic twin pairs (15 vs. 0%; p = 0.016).CONCLUSION: An estimated concordance rate of 15% (95% CI 0.059-0.31) is modest, but given the rarity of MPNs this finding is clinically relevant and provides further support for the role of genetic predisposition in the development of MPNs.",

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author = "Andersen, {Michael Asger} and Bjerrum, {Ole Weis} and Ajenthen Ranjan and Vibe Skov and Kruse, {Torben A} and Mads Thomassen and Axel Skytthe and Hasselbalch, {Hans Carl} and Kaare Christensen",

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T1 - Myeloproliferative Neoplasms in Danish Twins

AU - Andersen, Michael Asger

AU - Bjerrum, Ole Weis

AU - Ranjan, Ajenthen

AU - Skov, Vibe

AU - Kruse, Torben A

AU - Thomassen, Mads

AU - Skytthe, Axel

AU - Hasselbalch, Hans Carl

AU - Christensen, Kaare

PY - 2018/5/1

Y1 - 2018/5/1

N2 - OBJECTIVE: Myeloproliferative neoplasms (MPNs) are a heterogeneous group of diseases characterized by clonal hyperproliferation of immature and mature cells of the myeloid lineage. Genetic differences have been proposed to play a role in the development of MPNs. Monozygotic twin pairs with MPNs have been reported in a few case reports, but the MPN concordance pattern in twins remains unknown.METHOD: All twin pairs born in the period 1900-2010 were identified in the nationwide Danish Twin Registry. Only pairs with both twins alive on January 1, 1977, and those born thereafter were included to allow identification in the Danish National Patient Registry.RESULTS: A total of 158 twin pairs were registered with an MPN diagnosis: 36 monozygotic, 104 dizygotic, and 18 pairs with unknown zygosity. MPNs were diagnosed in both twins in 4 pairs. The probandwise concordance rates for monozygotic twin pairs were higher than for dizygotic twin pairs (15 vs. 0%; p = 0.016).CONCLUSION: An estimated concordance rate of 15% (95% CI 0.059-0.31) is modest, but given the rarity of MPNs this finding is clinically relevant and provides further support for the role of genetic predisposition in the development of MPNs.

AB - OBJECTIVE: Myeloproliferative neoplasms (MPNs) are a heterogeneous group of diseases characterized by clonal hyperproliferation of immature and mature cells of the myeloid lineage. Genetic differences have been proposed to play a role in the development of MPNs. Monozygotic twin pairs with MPNs have been reported in a few case reports, but the MPN concordance pattern in twins remains unknown.METHOD: All twin pairs born in the period 1900-2010 were identified in the nationwide Danish Twin Registry. Only pairs with both twins alive on January 1, 1977, and those born thereafter were included to allow identification in the Danish National Patient Registry.RESULTS: A total of 158 twin pairs were registered with an MPN diagnosis: 36 monozygotic, 104 dizygotic, and 18 pairs with unknown zygosity. MPNs were diagnosed in both twins in 4 pairs. The probandwise concordance rates for monozygotic twin pairs were higher than for dizygotic twin pairs (15 vs. 0%; p = 0.016).CONCLUSION: An estimated concordance rate of 15% (95% CI 0.059-0.31) is modest, but given the rarity of MPNs this finding is clinically relevant and provides further support for the role of genetic predisposition in the development of MPNs.

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KW - Aged

KW - Denmark/epidemiology

KW - Disease Susceptibility

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Myeloproliferative Disorders/epidemiology

KW - Population Surveillance

KW - Registries

KW - Twins/statistics & numerical data

KW - Twins, Dizygotic

KW - Twins, Monozygotic

U2 - 10.1159/000488384

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JO - Acta Haematologica

JF - Acta Haematologica

IS - 3

ER -

Myeloproliferative Neoplasms in Danish Twins

Abstract

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