Muscle-selective disinhibition of corticomotor representations using a motor imagery-based brain-computer interface

Mitsuaki Takemi; Tsuyoshi Maeda; Yoshihisa Masakado; Hartwig Roman Siebner; Junichi Ushiba

doi:10.1016/j.neuroimage.2018.08.070

Muscle-selective disinhibition of corticomotor representations using a motor imagery-based brain-computer interface

Mitsuaki Takemi, Tsuyoshi Maeda, Yoshihisa Masakado, Hartwig Roman Siebner, Junichi Ushiba

Institut for Klinisk Medicin

8 Citationer (Scopus)

Abstract

Bridging between brain activity and machine control, brain-computer interface (BCI) can be employed to activate distributed neural circuits implicated in a specific aspect of motor control. Using a motor imagery-based BCI paradigm, we previously found a disinhibition within the primary motor cortex contralateral to the imagined movement, as evidenced by event-related desynchronization (ERD) of oscillatory cortical activity. Yet it is unclear whether this BCI approach does selectively facilitate corticomotor representations targeted by the imagery. To address this question, we used brain state-dependent transcranial magnetic stimulation while participants performed kinesthetic motor imagery of wrist movements with their right hand and received online visual feedback of the ERD. Single and paired-pulse magnetic stimulation were given to the left primary motor cortex at a low or high level of ERD to assess intracortical excitability. While intracortical facilitation showed no modulation by ERD, short-latency intracortical inhibition was reduced the higher the ERD. Intracortical disinhibition was only found in the agonist muscle targeted by motor imagery at high ERD level, but not in the antagonist muscle. Single pulse motor-evoked potential was also increased the higher the ERD. However, at high ERD level, this facilitatory effect on overall corticospinal excitability was not selective to the agonist muscle. Analogous results were found in two independent experiments, in which participants either performed kinesthetic motor imagery of wrist extension or flexion. Our results showed that motor imagery-based BCI can selectively disinhibit the corticomotor output to the agonist muscle, enabling effector-specific training in patients with motor paralysis.

Originalsprog	Engelsk
Tidsskrift	NeuroImage
Vol/bind	183
Sider (fra-til)	597-605
ISSN	1053-8119
DOI	https://doi.org/10.1016/j.neuroimage.2018.08.070
Status	Udgivet - dec. 2018

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10.1016/j.neuroimage.2018.08.070

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title = "Muscle-selective disinhibition of corticomotor representations using a motor imagery-based brain-computer interface",

abstract = "Bridging between brain activity and machine control, brain-computer interface (BCI) can be employed to activate distributed neural circuits implicated in a specific aspect of motor control. Using a motor imagery-based BCI paradigm, we previously found a disinhibition within the primary motor cortex contralateral to the imagined movement, as evidenced by event-related desynchronization (ERD) of oscillatory cortical activity. Yet it is unclear whether this BCI approach does selectively facilitate corticomotor representations targeted by the imagery. To address this question, we used brain state-dependent transcranial magnetic stimulation while participants performed kinesthetic motor imagery of wrist movements with their right hand and received online visual feedback of the ERD. Single and paired-pulse magnetic stimulation were given to the left primary motor cortex at a low or high level of ERD to assess intracortical excitability. While intracortical facilitation showed no modulation by ERD, short-latency intracortical inhibition was reduced the higher the ERD. Intracortical disinhibition was only found in the agonist muscle targeted by motor imagery at high ERD level, but not in the antagonist muscle. Single pulse motor-evoked potential was also increased the higher the ERD. However, at high ERD level, this facilitatory effect on overall corticospinal excitability was not selective to the agonist muscle. Analogous results were found in two independent experiments, in which participants either performed kinesthetic motor imagery of wrist extension or flexion. Our results showed that motor imagery-based BCI can selectively disinhibit the corticomotor output to the agonist muscle, enabling effector-specific training in patients with motor paralysis.",

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author = "Mitsuaki Takemi and Tsuyoshi Maeda and Yoshihisa Masakado and Siebner, {Hartwig Roman} and Junichi Ushiba",

note = "Copyright {\textcopyright} 2018. Published by Elsevier Inc.",

year = "2018",

month = dec,

doi = "10.1016/j.neuroimage.2018.08.070",

language = "English",

volume = "183",

pages = "597--605",

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T1 - Muscle-selective disinhibition of corticomotor representations using a motor imagery-based brain-computer interface

AU - Takemi, Mitsuaki

AU - Maeda, Tsuyoshi

AU - Masakado, Yoshihisa

AU - Siebner, Hartwig Roman

AU - Ushiba, Junichi

PY - 2018/12

Y1 - 2018/12

N2 - Bridging between brain activity and machine control, brain-computer interface (BCI) can be employed to activate distributed neural circuits implicated in a specific aspect of motor control. Using a motor imagery-based BCI paradigm, we previously found a disinhibition within the primary motor cortex contralateral to the imagined movement, as evidenced by event-related desynchronization (ERD) of oscillatory cortical activity. Yet it is unclear whether this BCI approach does selectively facilitate corticomotor representations targeted by the imagery. To address this question, we used brain state-dependent transcranial magnetic stimulation while participants performed kinesthetic motor imagery of wrist movements with their right hand and received online visual feedback of the ERD. Single and paired-pulse magnetic stimulation were given to the left primary motor cortex at a low or high level of ERD to assess intracortical excitability. While intracortical facilitation showed no modulation by ERD, short-latency intracortical inhibition was reduced the higher the ERD. Intracortical disinhibition was only found in the agonist muscle targeted by motor imagery at high ERD level, but not in the antagonist muscle. Single pulse motor-evoked potential was also increased the higher the ERD. However, at high ERD level, this facilitatory effect on overall corticospinal excitability was not selective to the agonist muscle. Analogous results were found in two independent experiments, in which participants either performed kinesthetic motor imagery of wrist extension or flexion. Our results showed that motor imagery-based BCI can selectively disinhibit the corticomotor output to the agonist muscle, enabling effector-specific training in patients with motor paralysis.

AB - Bridging between brain activity and machine control, brain-computer interface (BCI) can be employed to activate distributed neural circuits implicated in a specific aspect of motor control. Using a motor imagery-based BCI paradigm, we previously found a disinhibition within the primary motor cortex contralateral to the imagined movement, as evidenced by event-related desynchronization (ERD) of oscillatory cortical activity. Yet it is unclear whether this BCI approach does selectively facilitate corticomotor representations targeted by the imagery. To address this question, we used brain state-dependent transcranial magnetic stimulation while participants performed kinesthetic motor imagery of wrist movements with their right hand and received online visual feedback of the ERD. Single and paired-pulse magnetic stimulation were given to the left primary motor cortex at a low or high level of ERD to assess intracortical excitability. While intracortical facilitation showed no modulation by ERD, short-latency intracortical inhibition was reduced the higher the ERD. Intracortical disinhibition was only found in the agonist muscle targeted by motor imagery at high ERD level, but not in the antagonist muscle. Single pulse motor-evoked potential was also increased the higher the ERD. However, at high ERD level, this facilitatory effect on overall corticospinal excitability was not selective to the agonist muscle. Analogous results were found in two independent experiments, in which participants either performed kinesthetic motor imagery of wrist extension or flexion. Our results showed that motor imagery-based BCI can selectively disinhibit the corticomotor output to the agonist muscle, enabling effector-specific training in patients with motor paralysis.

KW - Adult

KW - Brain Waves/physiology

KW - Brain-Computer Interfaces

KW - Electroencephalography/methods

KW - Electroencephalography Phase Synchronization/physiology

KW - Evoked Potentials, Motor/physiology

KW - Feedback, Sensory/physiology

KW - Female

KW - Humans

KW - Imagination/physiology

KW - Male

KW - Motor Activity/physiology

KW - Motor Cortex/physiology

KW - Muscle, Skeletal/physiology

KW - Neural Inhibition/physiology

KW - Transcranial Magnetic Stimulation/methods

KW - Young Adult

U2 - 10.1016/j.neuroimage.2018.08.070

DO - 10.1016/j.neuroimage.2018.08.070

M3 - Journal article

C2 - 30172003

SN - 1053-8119

VL - 183

SP - 597

EP - 605

JO - NeuroImage

JF - NeuroImage

ER -

Muscle-selective disinhibition of corticomotor representations using a motor imagery-based brain-computer interface

Abstract

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