Muscle imaging in patients with tubular aggregate myopathy caused by mutations in STIM1

TY - JOUR

T1 - Muscle imaging in patients with tubular aggregate myopathy caused by mutations in STIM1

AU - Tasca, Giorgio

AU - D'Amico, Adele

AU - Monforte, Mauro

AU - Nadaj-Pakleza, Aleksandra

AU - Vialle, Marc

AU - Fattori, Fabiana

AU - Vissing, John

AU - Ricci, Enzo

AU - Bertini, Enrico

N1 - Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.

PY - 2015/11

Y1 - 2015/11

N2 - Tubular aggregate myopathy is a genetically heterogeneous disease characterized by tubular aggregates as the hallmark on muscle biopsy. Mutations in STIM1 have recently been identified as one genetic cause in a number of tubular aggregate myopathy cases. To characterize the pattern of muscle involvement in this disease, upper and lower girdles and lower limbs were imaged in five patients with mutations in STIM1, and the scans were compared with two patients with tubular aggregate myopathy not caused by mutations in STIM1. A common pattern of involvement was found in STIM1-mutated patients, although with variable extent and severity of lesions. In the upper girdle, the subscapularis muscle was invariably affected. In the lower limbs, all the patients showed a consistent involvement of the flexor hallucis longus, which is very rarely affected in other muscle diseases, and a diffuse involvement of thigh and posterior leg with sparing of gracilis, tibialis anterior and, to a lesser extent, short head of biceps femoris. Mutations in STIM1 are associated with a homogeneous involvement on imaging despite variable clinical features. Muscle imaging can be useful in identifying STIM1-mutated patients especially among other forms of tubular aggregate myopathy.

AB - Tubular aggregate myopathy is a genetically heterogeneous disease characterized by tubular aggregates as the hallmark on muscle biopsy. Mutations in STIM1 have recently been identified as one genetic cause in a number of tubular aggregate myopathy cases. To characterize the pattern of muscle involvement in this disease, upper and lower girdles and lower limbs were imaged in five patients with mutations in STIM1, and the scans were compared with two patients with tubular aggregate myopathy not caused by mutations in STIM1. A common pattern of involvement was found in STIM1-mutated patients, although with variable extent and severity of lesions. In the upper girdle, the subscapularis muscle was invariably affected. In the lower limbs, all the patients showed a consistent involvement of the flexor hallucis longus, which is very rarely affected in other muscle diseases, and a diffuse involvement of thigh and posterior leg with sparing of gracilis, tibialis anterior and, to a lesser extent, short head of biceps femoris. Mutations in STIM1 are associated with a homogeneous involvement on imaging despite variable clinical features. Muscle imaging can be useful in identifying STIM1-mutated patients especially among other forms of tubular aggregate myopathy.

U2 - 10.1016/j.nmd.2015.07.008

DO - 10.1016/j.nmd.2015.07.008

M3 - Journal article

C2 - 26255678

SN - 0960-8966

VL - 25

SP - 898

EP - 903

JO - Journal of Neuromuscular Diseases

JF - Journal of Neuromuscular Diseases

IS - 11

ER -