Muscle contractility of leg muscles in patients with mitochondrial myopathies

TY - JOUR

T1 - Muscle contractility of leg muscles in patients with mitochondrial myopathies

AU - Poulsen, Nanna Scharff

AU - Dahlqvist, Julia Rebecka

AU - Hedermann, Gitte

AU - Løkken, Nicoline

AU - Vissing, John

PY - 2019/5

Y1 - 2019/5

N2 - Background: The primary disease mechanism underlying mitochondrial myopathies (MM) is impaired energy generation to support muscle endurance. Little is known about muscle contractility before energy becomes deficient during muscle contractions. We investigated muscle contractility in MM to uncover potentially fixed weakness aspects of the disorders. Methods: Contractility of calf and thigh muscles was investigated by comparing strength with contractile cross-sectional area (CCSA) of the used muscles, as measured by stationary dynamometry and MRI, respectively. Results and discussion: Our findings suggest reduced contractile properties in thigh and calf muscles of patients with MM.

AB - Background: The primary disease mechanism underlying mitochondrial myopathies (MM) is impaired energy generation to support muscle endurance. Little is known about muscle contractility before energy becomes deficient during muscle contractions. We investigated muscle contractility in MM to uncover potentially fixed weakness aspects of the disorders. Methods: Contractility of calf and thigh muscles was investigated by comparing strength with contractile cross-sectional area (CCSA) of the used muscles, as measured by stationary dynamometry and MRI, respectively. Results and discussion: Our findings suggest reduced contractile properties in thigh and calf muscles of patients with MM.

U2 - 10.1016/j.mito.2018.07.001

DO - 10.1016/j.mito.2018.07.001

M3 - Journal article

C2 - 30017555

AN - SCOPUS:85050891196

SN - 1567-7249

VL - 46

SP - 221

EP - 227

JO - Mitochondrion

JF - Mitochondrion

ER -