TY - JOUR
T1 - Multistationarity and Bistability for Fewnomial Chemical Reaction Networks
AU - Feliu, Elisenda
AU - Helmer, Martin
PY - 2019
Y1 - 2019
N2 - Bistability and multistationarity are properties of reaction networks linked to switch-like responses and connected to cell memory and cell decision making. Determining whether and when a network exhibits bistability is a hard and open mathematical problem. One successful strategy consists of analyzing small networks and deducing that some of the properties are preserved upon passage to the full network. Motivated by this, we study chemical reaction networks with few chemical complexes. Under mass action kinetics, the steady states of these networks are described by fewnomial systems, that is polynomial systems having few distinct monomials. Such systems of polynomials are often studied in real algebraic geometry by the use of Gale dual systems. Using this Gale duality, we give precise conditions in terms of the reaction rate constants for the number and stability of the steady states of families of reaction networks with one non-flow reaction.
AB - Bistability and multistationarity are properties of reaction networks linked to switch-like responses and connected to cell memory and cell decision making. Determining whether and when a network exhibits bistability is a hard and open mathematical problem. One successful strategy consists of analyzing small networks and deducing that some of the properties are preserved upon passage to the full network. Motivated by this, we study chemical reaction networks with few chemical complexes. Under mass action kinetics, the steady states of these networks are described by fewnomial systems, that is polynomial systems having few distinct monomials. Such systems of polynomials are often studied in real algebraic geometry by the use of Gale dual systems. Using this Gale duality, we give precise conditions in terms of the reaction rate constants for the number and stability of the steady states of families of reaction networks with one non-flow reaction.
KW - Chemical reaction networks
KW - Fewnomial systems
KW - Gale duality
KW - Multistationarity and bistability
KW - Real algebraic geometry
KW - Steady states of dynamical systems
UR - http://www.scopus.com/inward/record.url?scp=85058847056&partnerID=8YFLogxK
U2 - 10.1007/s11538-018-00555-z
DO - 10.1007/s11538-018-00555-z
M3 - Journal article
C2 - 30564990
AN - SCOPUS:85058847056
SN - 0092-8240
VL - 81
SP - 1089
EP - 1121
JO - Bulletin of Mathematical Biology
JF - Bulletin of Mathematical Biology
IS - 4
ER -