Multiple self-healing squamous epithelioma er en arvelig tilstand med selvhelende hudkræft

TY - JOUR

T1 - Multiple self-healing squamous epithelioma er en arvelig tilstand med selvhelende hudkræft

AU - Broesby-Olsen, Sigurd

AU - Frandsen, Stine Krog

AU - Thomassen, Mads

AU - Brandrup, Flemming

AU - Gerdes, Anne-Marie

PY - 2012/4/23

Y1 - 2012/4/23

N2 - Multiple self-healing squamous epithelioma - Ferguson-Smith disease (MSSE) is an autosomal dominant inherited disease with multiple, recurrent, histologically malignant tumours that undergo spontaneous regression. The gene for MSSE has recently been identified as the transforming growth factor-beta receptor 1 (TGFBR1). Although rare, MSSE constitutes an important model of tumour-biology research. The discovery of the genetic background for MSSE paves the way for further elucidating the mechanisms involved in this peculiar self-healing cancer syndrome.

AB - Multiple self-healing squamous epithelioma - Ferguson-Smith disease (MSSE) is an autosomal dominant inherited disease with multiple, recurrent, histologically malignant tumours that undergo spontaneous regression. The gene for MSSE has recently been identified as the transforming growth factor-beta receptor 1 (TGFBR1). Although rare, MSSE constitutes an important model of tumour-biology research. The discovery of the genetic background for MSSE paves the way for further elucidating the mechanisms involved in this peculiar self-healing cancer syndrome.

KW - Carcinoma, Squamous Cell

KW - Humans

KW - Keratoacanthoma

KW - Mutation

KW - Neoplasm Regression, Spontaneous

KW - Neoplasms, Multiple Primary

KW - Neoplastic Syndromes, Hereditary

KW - Receptors, Transforming Growth Factor beta

KW - Skin Neoplasms

M3 - Tidsskriftartikel

C2 - 22533930

SN - 0041-5782

VL - 174

SP - 1149

EP - 1151

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 17

ER -