Multimodel inference applied to oxygen recovery kinetics after 6-min walk tests in patients with chronic obstructive pulmonary disease

TY - JOUR

T1 - Multimodel inference applied to oxygen recovery kinetics after 6-min walk tests in patients with chronic obstructive pulmonary disease

AU - Baty, Florent

AU - Ritz, Christian

AU - Jensen, Signe Marie

AU - Kern, Lukas

AU - Tamm, Michael

AU - Brutsche, Martin Hugo

N1 - CURIS 2017 NEXS 299

PY - 2017/11

Y1 - 2017/11

N2 - 6-min walk tests (6MWT) are routinely performed in patients with chronic obstructive pulmonary disease (COPD). Oxygen uptake (V̇O2) kinetics during 6MWT can be modeled and derived parameters provide indicators of patients’ exercise capacity. Post-exercise V̇O2 recovery also provides important parameters of patients’ fitness which has not been extensively investigated in COPD. Several nonlinear regression models with different underlying biological assumptions may be suitable for describing recovery kinetics. Multimodel inference (model averaging) can then be used to capture the uncertainty in considering several models. Our aim was to apply multimodel inference in order to better understand the physiological underpinnings of V̇O2 recovery after 6MWT in patients with COPD. 61 patients with COPD (stages 2 to 4) were included in this study. Oxygen kinetics during 6MWT were modeled using nonlinear regression. Three statistical approaches (mixed-effects, meta-analysis and weighted regression) were compared in order to summarize estimates obtained from multiple kinetics. The recovery phase was modeled using 3 distinct equations (log-logistic, Weibull 1 and Weibull 2). Three models were fitted to the set of 61 kinetics. A significant model-averaged difference of 40.39 sec (SE = 17.1) in the time to half decrease of V̇O2 level (T1/2V̇O2) was found between stage 2 and 4 (p = 0.0178). In addition, the Weibull 1 model characterized by a steeper decrease at the beginning of the recovery phase showed some improvement of goodness of fit when fitted to the kinetics of patients with stage 2 COPD in comparison with the 2 other models. Multimodel inference was successfully used to model V̇O2 recovery after 6MWT in patients with COPD. Significant model-averaged differences in T1/2V̇O2 were found between moderate and very severe COPD patients. Furthermore, specific patterns of V̇O2 recovery could be identified across COPD stages.

AB - 6-min walk tests (6MWT) are routinely performed in patients with chronic obstructive pulmonary disease (COPD). Oxygen uptake (V̇O2) kinetics during 6MWT can be modeled and derived parameters provide indicators of patients’ exercise capacity. Post-exercise V̇O2 recovery also provides important parameters of patients’ fitness which has not been extensively investigated in COPD. Several nonlinear regression models with different underlying biological assumptions may be suitable for describing recovery kinetics. Multimodel inference (model averaging) can then be used to capture the uncertainty in considering several models. Our aim was to apply multimodel inference in order to better understand the physiological underpinnings of V̇O2 recovery after 6MWT in patients with COPD. 61 patients with COPD (stages 2 to 4) were included in this study. Oxygen kinetics during 6MWT were modeled using nonlinear regression. Three statistical approaches (mixed-effects, meta-analysis and weighted regression) were compared in order to summarize estimates obtained from multiple kinetics. The recovery phase was modeled using 3 distinct equations (log-logistic, Weibull 1 and Weibull 2). Three models were fitted to the set of 61 kinetics. A significant model-averaged difference of 40.39 sec (SE = 17.1) in the time to half decrease of V̇O2 level (T1/2V̇O2) was found between stage 2 and 4 (p = 0.0178). In addition, the Weibull 1 model characterized by a steeper decrease at the beginning of the recovery phase showed some improvement of goodness of fit when fitted to the kinetics of patients with stage 2 COPD in comparison with the 2 other models. Multimodel inference was successfully used to model V̇O2 recovery after 6MWT in patients with COPD. Significant model-averaged differences in T1/2V̇O2 were found between moderate and very severe COPD patients. Furthermore, specific patterns of V̇O2 recovery could be identified across COPD stages.

KW - Journal Article

U2 - 10.1371/journal.pone.0187548

DO - 10.1371/journal.pone.0187548

M3 - Journal article

C2 - 29117249

SN - 1932-6203

VL - 12

JO - PLoS Computational Biology

JF - PLoS Computational Biology

IS - 11

M1 - e0187548

ER -