Multicenter European Prevalence Study of Neurocognitive Impairment and Associated Factors in HIV Positive Patients

TY - JOUR

T1 - Multicenter European Prevalence Study of Neurocognitive Impairment and Associated Factors in HIV Positive Patients

AU - Haddow, Lewis J

AU - Laverick, Rosanna

AU - Daskalopoulou, Marina

AU - McDonnell, Jeffrey

AU - Lampe, Fiona C

AU - Gilson, Richard

AU - Speakman, Andrew

AU - Antinori, Andrea

AU - Balestra, Pietro

AU - Bruun, Tina

AU - Gerstoft, Jan

AU - Nielsen, Lars

AU - Vassilenko, Anna

AU - Collins, Simon

AU - Rodger, Alison J

AU - Cognitive Impairment in People with HIV in the European Region (CIPHER) Study Group

PY - 2018/5/1

Y1 - 2018/5/1

N2 - We conducted a cross-sectional study in 448 HIV positive patients attending five European outpatient clinics to determine prevalence of and factors associated with neurocognitive impairment (NCI) using computerized and pen-and-paper neuropsychological tests. NCI was defined as a normalized Z score ≤-1 in at least 2 out of 5 cognitive domains. Participants' mean age was 45.8 years; 84% male; 87% white; 56% university educated; median CD4 count 550 cells/mm3; 89% on antiretroviral therapy. 156 (35%) participants had NCI, among whom 26 (17%; 5.8% overall) reported a decline in activities of daily living. Prevalence of NCI was lower in those always able to afford basic needs (adjusted prevalence ratio [aPR] 0.71, 95% confidence interval [CI] 0.54-0.94) or with a university education (aPR 0.72, 95% CI 0.54-0.97) and higher in those with severe depressive symptoms (aPR 1.53, 95% CI 1.09-2.14) or a significant comorbid condition (aPR 1.40, 95% CI 1.03-1.90).

AB - We conducted a cross-sectional study in 448 HIV positive patients attending five European outpatient clinics to determine prevalence of and factors associated with neurocognitive impairment (NCI) using computerized and pen-and-paper neuropsychological tests. NCI was defined as a normalized Z score ≤-1 in at least 2 out of 5 cognitive domains. Participants' mean age was 45.8 years; 84% male; 87% white; 56% university educated; median CD4 count 550 cells/mm3; 89% on antiretroviral therapy. 156 (35%) participants had NCI, among whom 26 (17%; 5.8% overall) reported a decline in activities of daily living. Prevalence of NCI was lower in those always able to afford basic needs (adjusted prevalence ratio [aPR] 0.71, 95% confidence interval [CI] 0.54-0.94) or with a university education (aPR 0.72, 95% CI 0.54-0.97) and higher in those with severe depressive symptoms (aPR 1.53, 95% CI 1.09-2.14) or a significant comorbid condition (aPR 1.40, 95% CI 1.03-1.90).

U2 - 10.1007/s10461-017-1683-z

DO - 10.1007/s10461-017-1683-z

M3 - Journal article

C2 - 28144792

SN - 1090-7165

VL - 22

SP - 1573

EP - 1583

JO - AIDS and Behavior

JF - AIDS and Behavior

IS - 5

ER -