Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency

Pengyi Yang; Sean J Humphrey; Senthilkumar Cinghu; Rajneesh Pathania; Andrew J Oldfield; Dhirendra Kumar; Dinuka Perera; Jean Y H Yang; David E James; Matthias Mann; Raja Jothi

doi:10.1016/j.cels.2019.03.012

Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency

Pengyi Yang, Sean J Humphrey, Senthilkumar Cinghu, Rajneesh Pathania, Andrew J Oldfield, Dhirendra Kumar, Dinuka Perera, Jean Y H Yang, David E James, Matthias Mann, Raja Jothi

29 Citationer (Scopus)

Abstract

Cell signaling underlies transcriptional and/or epigenetic control of a vast majority of cell fate decisions during early embryonic development. Yet, the sequence of molecular and signaling events underlying pre- to post-implantation epiblast differentiation remains poorly understood. Through comprehensive mapping of the proteome, phosphoproteome, transcriptome, and epigenome of embryonic stem cells transitioning from naive to primed pluripotency, Yang et al. shed new insights on the multi-layered control of the phased progression of pluripotency.

Originalsprog	Engelsk
Tidsskrift	Cell Systems
Vol/bind	8
Udgave nummer	5
Sider (fra-til)	427-445.e10
ISSN	2405-4712
DOI	https://doi.org/10.1016/j.cels.2019.03.012
Status	Udgivet - 22 maj 2019
Udgivet eksternt	Ja

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10.1016/j.cels.2019.03.012

http://www.cell.com/article/S2405471219301152/pdfLicens: CC BY-NC-ND

Citationsformater

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title = "Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency",

abstract = "Cell signaling underlies transcriptional and/or epigenetic control of a vast majority of cell fate decisions during early embryonic development. Yet, the sequence of molecular and signaling events underlying pre- to post-implantation epiblast differentiation remains poorly understood. Through comprehensive mapping of the proteome, phosphoproteome, transcriptome, and epigenome of embryonic stem cells transitioning from naive to primed pluripotency, Yang et al. shed new insights on the multi-layered control of the phased progression of pluripotency.",

author = "Pengyi Yang and Humphrey, {Sean J} and Senthilkumar Cinghu and Rajneesh Pathania and Oldfield, {Andrew J} and Dhirendra Kumar and Dinuka Perera and Yang, {Jean Y H} and James, {David E} and Matthias Mann and Raja Jothi",

year = "2019",

month = may,

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doi = "10.1016/j.cels.2019.03.012",

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T1 - Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency

AU - Yang, Pengyi

AU - Humphrey, Sean J

AU - Cinghu, Senthilkumar

AU - Pathania, Rajneesh

AU - Oldfield, Andrew J

AU - Kumar, Dhirendra

AU - Perera, Dinuka

AU - Yang, Jean Y H

AU - James, David E

AU - Mann, Matthias

AU - Jothi, Raja

PY - 2019/5/22

Y1 - 2019/5/22

N2 - Cell signaling underlies transcriptional and/or epigenetic control of a vast majority of cell fate decisions during early embryonic development. Yet, the sequence of molecular and signaling events underlying pre- to post-implantation epiblast differentiation remains poorly understood. Through comprehensive mapping of the proteome, phosphoproteome, transcriptome, and epigenome of embryonic stem cells transitioning from naive to primed pluripotency, Yang et al. shed new insights on the multi-layered control of the phased progression of pluripotency.

AB - Cell signaling underlies transcriptional and/or epigenetic control of a vast majority of cell fate decisions during early embryonic development. Yet, the sequence of molecular and signaling events underlying pre- to post-implantation epiblast differentiation remains poorly understood. Through comprehensive mapping of the proteome, phosphoproteome, transcriptome, and epigenome of embryonic stem cells transitioning from naive to primed pluripotency, Yang et al. shed new insights on the multi-layered control of the phased progression of pluripotency.

U2 - 10.1016/j.cels.2019.03.012

DO - 10.1016/j.cels.2019.03.012

M3 - Journal article

C2 - 31078527

SN - 2405-4712

VL - 8

SP - 427-445.e10

JO - Cell Systems

JF - Cell Systems

IS - 5

ER -

Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency

Abstract

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