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mTORC2 Regulation of Muscle Metabolism and Insulin Sensitivity
Maximilian Kleinert
August Krogh Sektionen for Molekylær Fysiologi
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Keyphrases
Abrogation
11%
AMPK Activity
11%
Blood Glucose
66%
Early Events
11%
Eating
22%
Energy Substrates
11%
Fat Mass
11%
Forkhead Box O1 (FOXO1)
22%
Glucose Metabolism
11%
Glucose Transporter 4 (GLUT4)
33%
Glucose Uptake
22%
Glucose-stimulated Insulin Secretion
22%
GLUT4 Translocation
44%
Glycolytic Flux
22%
Healthy Individuals
11%
Insulin
88%
Insulin Binding
11%
Insulin Release
11%
Insulin Secretion
11%
Insulin Sensitivity
100%
Insulin Sensitizers
11%
Insulin Signaling
11%
Insulin Stimulation
11%
Intramyocellular Triacylglycerol
22%
Lipid Droplets
11%
Lipid Storage
22%
Liver Fat
11%
Low Blood Glucose
11%
Mammalian Target of Rapamycin (mTOR)
11%
Metabolism
11%
Molecular Mechanism
11%
Molecular Signaling
11%
Mouse Skeletal muscle
11%
MTOR Complex 2 (mTORC2)
100%
MTOR Inhibitor
11%
Muscle Cells
11%
Muscle Glycolysis
11%
Muscle Lipid
11%
Muscle Metabolism
100%
Organ Failure
11%
Pancreas
22%
Perilipin-3
22%
Physiological Relevance
11%
Plasma Membrane
33%
Protein Content
11%
Protein Expression
11%
Proteomic Analysis
11%
Signaling Axis
11%
Signaling Events
11%
Skeletal muscle
55%
Skeletal muscle Glucose Uptake
11%
Skeletal muscle Insulin Sensitivity
11%
Skeletal muscle Metabolism
11%
Susceptible Individuals
11%
Type 2 Diabetes Mellitus (T2DM)
33%
Understanding Why
11%
WT Mice
11%
Biochemistry, Genetics and Molecular Biology
AMP-activated Protein Kinase
22%
Cell Membrane
22%
Fat Mass
11%
Genetics
11%
Glucose Blood Level
66%
Glucose Metabolism
11%
Glucose Transport
55%
Glucose Transporter
11%
GLUT4
66%
Insulin Binding
11%
Insulin Release
22%
Insulin Sensitivity
100%
Insulin Signaling
11%
Lipid Droplet
11%
Lipid Storage
22%
Mammalian Target of Rapamycin
11%
Mammalian Target of Rapamycin Complex 2
100%
Metabolic Pathway
11%
Muscle Fiber Membrane
11%
Muscle Metabolism
100%
Perilipin
22%
Protein Content
11%
Protein Expression
11%
Proteomics
11%
Skeletal Muscle
88%
Skeletal Muscle Metabolism
11%
Triacylglycerol Level
11%
Triglyceride
11%
Wild Type Mouse
11%
Medicine and Dentistry
AMP-Activated Protein Kinase
22%
Blood Glucose
66%
Cell Membrane
22%
Doctor of Philosophy
11%
Fat Droplet
11%
Fatty Liver
11%
Glucose Metabolism
11%
Glucose Transporter 4
77%
Glucose Uptake
55%
Insulin Release
22%
Insulin Sensitivity
100%
Insulin Signaling
11%
Lipid Storage
22%
Mammalian Target of Rapamycin
11%
Mannose 6 Phosphate Receptor Binding Protein 1
22%
Maturity Onset Diabetes of the Young
33%
Muscle Fiber Membrane
11%
Muscle Metabolism
100%
Protein Expression
11%
Proteomics
11%
Receptor
11%
Skeletal Muscle
88%
Skeletal Muscle Metabolism
11%
Triacylglycerol
22%